Spindlin 1 anticorps (N-Term)

N° du produit ABIN5516939

Détail du produit anti-Spindlin 1 anticorps

Antigène: Spindlin 1 (SPIN1)

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Porc, Boeuf (Vache), Chien, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Spindlin 1 est non-conjugé

Application: Western Blotting (WB)

Séquence: KTPFGKTPGQ RSRADAGHAG VSANMMKKRT SHKKHRSSVG PSKPVSQPRR

Homologie: Cow: 100%, Dog: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against SPIN1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N-terminal region of Human SPIN1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur Spindlin 1

Antigène: Spindlin 1 (SPIN1)

Autre désignation: SPIN1 (SPIN1 Produits)

Synonymes: anticorps SPIN, anticorps AA553322, anticorps AA673430, anticorps Spin, anticorps spin, anticorps spindlin, anticorps MGC115436, anticorps Spindlin-1, anticorps DKFZp459K085, anticorps spindlin 1, anticorps spindlin 1 L homeolog, anticorps SPIN1, anticorps Spin1, anticorps spin1, anticorps spin1.L

Sujet: SPIN1 is a chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway dowstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed:24589551). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (PubMed:21960006).It may play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption.

Alias Symbols: SPIN1, OCR, SPIN,

Protein Interaction Partner: SUMO2, UBC, PRMT6, BAG3, NPM1, UBL4A, SMURF1, EIF4A3, YWHAE, MAGOH, GRK5, TCF3, ARRB2, ARRB1, ELAVL1, AGO3, PTN,

Protein Size: 262

ID gène: 10927

NCBI Accession: NP_006708

UniProt: Q9Y657