anticorps 0710008C12Rik, anticorps Fbxo37, anticorps RGD1306444, anticorps fbl15, anticorps fbxo37, anticorps FBXO37, anticorps Fbl15, anticorps JET, anticorps PSD, anticorps F4I10.140, anticorps F4I10_140, anticorps SLOW MOTION, anticorps fbxl15, anticorps zgc:85882, anticorps F-box and leucine-rich repeat protein 15, anticorps F-box and leucine-rich repeat protein 15 L homeolog, anticorps F-box and leucine rich repeat protein 15, anticorps F-box family protein, anticorps F-box only protein 37, anticorps Fbxl15, anticorps fbxl15.L, anticorps FBXL15, anticorps fbxl15, anticorps SLOMO, anticorps fbx37
Sujet
FBXL15 is a substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. It is required for dorsal/ventral pattern formation and bone mass maintenance and also mediates ubiquitination of SMURF2 and WWP2.