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SETD7 anticorps (N-Term)
SETD7
Reactivité: Humain, Souris, Rat, Chien, Cheval, Porc, Lapin, Boeuf (Vache), Poisson zèbre (Danio rerio), Cobaye
WB
Hôte: Lapin
Polyclonal
unconjugated
N° du produit ABIN5517321
Détail du produit anti-SETD7 anticorps
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Antigène
Voir toutes SETD7 Anticorps
SETD7
(SET Domain Containing (Lysine Methyltransferase) 7 (SETD7))
Épitope
Tous les épitopes à travers SETD7 Anticorps.
N-Term
Reactivité
Toutes les réactivités sur SETD7 Anticorps
Humain, Souris, Rat, Chien, Cheval, Porc, Lapin, Boeuf (Vache), Poisson zèbre (Danio rerio), Cobaye
Hôte
Toutes les hôtes sur SETD7 Anticorps
Lapin
Clonalité
Toutes les clonalités sur SETD7 Anticorps
Polyclonal
Conjugué
Tous les conjugués à travers SETD7 Anticorps
Cet anticorp SETD7 est non-conjugé
Application
Tous les applications à travers SETD7 Anticorps.
Western Blotting (WB)
Séquence
MDSDDEMVEE AVEGHLDDDG LPHGFCTVTY SSTDRFEGNF VHGEKNGRGK
Homologie
Cow: 93%, Dog: 93%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 92%
Attributs du produit
This is a rabbit polyclonal antibody against SETD7. It was validated on Western Blot.
Purification
Affinity purified
Immunogène
The immunogen is a synthetic peptide directed towards the N-terminal region of Human SETD7
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Information d'application
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Indications d'application
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Stockage
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Format
Liquid
Buffer
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
-20 °C
Stockage commentaire
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Détails sur SETD7
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Antigène
SETD7
(SET Domain Containing (Lysine Methyltransferase) 7 (SETD7))
Autre désignation
SETD7 (SETD7 Produits )
Synonymes
anticorps KMT7, anticorps SET7, anticorps SET7/9, anticorps SET9, anticorps set7, anticorps zgc:101860, anticorps zgc:92330, anticorps 1600028F23Rik, anticorps H3K4MT, anticorps Set7, anticorps Set7/9, anticorps mKIAA1717, anticorps SET domain containing lysine methyltransferase 7, anticorps SET domain containing (lysine methyltransferase) 7, anticorps SETD7, anticorps setd7, anticorps Setd7
Sujet
SETD7 is a histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. It plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Alias Symbols: SETD7, KIAA1717, KMT7, SET7, SET9, Protein Interaction Partner: KLF4, HIST3H3, SOX2, PRKAR1A, A1BG, TP53, NR2F2, STEAP3, SERTAD1, DPY30, MED1, MYOD1, E2F1, HIST1H3A, SMARCA4, H3F3A, STAT3, RELA, AR, UBC, DNMT1, PPP1R12A, SIRT1, TBP, TAF10, TAF7, TAF6, HIST1H4A, ESR1, HIST2H3C, HCFC1, L3MBTL1, Protein Size: 366
ID gène
80854
NCBI Accession
NP_085151
UniProt
Q8WTS6
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