WDR48 anticorps (C-Term)

N° du produit ABIN5517644

Détail du produit anti-WDR48 anticorps

Antigène: WDR48 (WD Repeat Domain 48 (WDR48))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp WDR48 est non-conjugé

Application: Western Blotting (WB)

Séquence: YEKIINLDNE SQTTSSSNNE KPGEQEKEED IAVLAEEKIE LLCQDQVLDP

Purification: Affinity purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human WDR48

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur WDR48

Antigène: WDR48 (WD Repeat Domain 48 (WDR48))

Autre désignation: WDR48 (WDR48 Produits)

Synonymes: anticorps P80, anticorps UAF1, anticorps 8430408H12Rik, anticorps mKIAA1449, anticorps WD repeat domain 48, anticorps WDR48, anticorps Wdr48

Sujet: Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 and USP46 (PubMed:18082604, PubMed:19075014, PubMed:26388029). Enhances the USP1-mediated deubiquitination of FANCD2, USP1 being almost inactive by itself (PubMed:18082604). Also activates deubiquitinating activity of complexes containing USP12 (PubMed:19075014). Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. In case of infection by Herpesvirus saimiri, may play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. Induces lysosomal vesicle formation via interaction with Herpesvirus saimiri tyrosine kinase-interacting protein (TIP). Subsequently, TIP recruits tyrosine-protein kinase LCK, resulting in down-regulation of T-cell antigen receptor TCR. May play a role in generation of enlarged endosomal vesicles via interaction with TIP. In case of infection by papillomavirus HPV11, promotes the maintenance of the viral genome via its interaction with HPV11 helicase E1.

Alias Symbols: P80, UAF1, SPG60

Protein Size: 677

ID gène: 57599

NCBI Accession: NM_001303402, NP_065890

UniProt: Q8TAF3