DISC1 anticorps (Middle Region)

N° du produit ABIN5518699

Détail du produit anti-DISC1 anticorps

Antigène: DISC1 (Disrupted in Schizophrenia 1 (DISC1))

Épitope: AA 461-477, Middle Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DISC1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Fonction: Rabbit IgG polyclonal antibody for Disrupted in schizophrenia 1 protein(DISC1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.

Séquence: EKQQLQKEIE ALQARMF

Réactivité croisée (Details): No cross reactivity with other proteins.

Attributs du produit: Rabbit IgG polyclonal antibody for Disrupted in schizophrenia 1 protein(DISC1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: disrupted in schizophrenia 1
Protein Name: Disrupted in schizophrenia 1 protein

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence in the middle region of human DISC1(461-477aa EKQQLQKEIEALQARMF), different from the related mouse sequence by two amino acids, and from the related rat sequence by four amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide, Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Détails sur DISC1

Antigène: DISC1 (Disrupted in Schizophrenia 1 (DISC1))

Autre désignation: DISC1 (DISC1 Produits)

Synonymes: anticorps DISC1, anticorps C1orf136, anticorps SCZD9, anticorps disrupted in schizophrenia 1, anticorps disrupted in schizophrenia 1 protein, anticorps disc1, anticorps DISC1, anticorps LOC100580606, anticorps Disc1

Sujet: DISC1(Disrupted in Schizophrenia 1), is a protein that is encoded by the DISC1 gene in humans. Ma et al.(2002) determined that the mouse Disc1 gene maps to chromosome 8 in a region with homology of synteny to human chromosome 1q42. Ozeki et al.(2003) demonstrated that rodent Disc1 expression displayed pronounced developmental regulation, with the highest levels in late embryonic life during development of the cerebral cortex. Millar et al.(2005) showed that DISC1 interacts with the UCR2 domain of phosphodiesterase-4B, implicated in susceptibility to schizophrenia, and that elevation of cellular cAMP leads to dissociation of PDE4B from DISC1 and in increase in PDE4B activity.

Synonyms: C1orf136 antibody|DISC1 antibody|DISC1_HUMAN antibody|Disrupted in schizophrenia 1 antibody|Disrupted in schizophrenia 1 protein antibody|KIAA0457 antibody|RP4-730B13.1 antibody|SCZD9 antibody

Pathways: Regulation of Cell Size