ARNT anticorps (AA 513-544)

N° du produit ABIN5530297

Détail du produit anti-ARNT anticorps

Antigène: ARNT (Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT))

Épitope: AA 513-544

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ARNT est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogène: This ARNT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 513-544 amino acids from the Central region of human ARNT.

Isotype: Ig Fraction

Information d'application

Indications d'application: For IF starting dilution is: 1:10~50

For WB starting dilution is: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 2 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur ARNT

Antigène: ARNT (Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT))

Autre désignation: ARNT (ARNT Produits)

Synonymes: anticorps HIF-1-beta, anticorps HIF-1beta, anticorps HIF1-beta, anticorps HIF1B, anticorps HIF1BETA, anticorps TANGO, anticorps bHLHe2, anticorps D3Ertd557e, anticorps Drnt, anticorps ESTM42, anticorps Hif1b, anticorps W08714, anticorps mKIAA4051, anticorps Arnt1, anticorps ARNT, anticorps zgc:136664, anticorps arnt1, anticorps hif1b, anticorps tango, anticorps xArnt, anticorps hif1beta, anticorps hif-1beta, anticorps arnt.2, anticorps MGC68805, anticorps aryl hydrocarbon receptor nuclear translocator, anticorps aryl hydrocarbon receptor nuclear translocator S homeolog, anticorps ARNT, anticorps Arnt, anticorps arnt, anticorps arnt.S

Sujet: The aryl hydrocarbon (Ah) receptor is involved in the induction of several enzymes that participate in xenobiotic metabolism. The ligand-free, cytosolic form of the Ah receptor is complexed to heat shock protein 90. Binding of ligand, which includes dioxin and polycyclic aromatic hydrocarbons, results in translocation of the ligand-binding subunit only to the nucleus. Induction of enzymes involved in xenobiotic metabolism occurs through binding of the ligand-bound Ah receptor to xenobiotic responsive elements in the promoters of genes for these enzymes. This gene encodes a protein that forms a complex with the ligand-bound Ah receptor, and is required for receptor function. The encoded protein has also been identified as the beta subunit of a heterodimeric transcription factor, hypoxia-inducible factor 1. A t(1,12)(q21,p13) translocation, which results in a TEL-ARNT fusion protein, is associated with acute myeloblastic leukemia. Alternative splicing results in multiple transcript variants.

Poids moléculaire: 87 kDa

ID gène: 405

UniProt: P27540

Pathways: Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Regulation of Carbohydrate Metabolic Process, Signaling Events mediated by VEGFR1 and VEGFR2, L'effet Warburg