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GCAP1 anticorps (C-Term)

GUCA1A Reactivité: Humain WB, IHC (p) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN5531246
  • Antigène Voir toutes GCAP1 (GUCA1A) Anticorps
    GCAP1 (GUCA1A) (Guanylate Cyclase Activator 1A (Retina) (GUCA1A))
    Épitope
    • 15
    • 8
    • 5
    • 3
    • 1
    • 1
    • 1
    AA 160-191, C-Term
    Reactivité
    • 20
    • 18
    • 17
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 34
    • 1
    Lapin
    Clonalité
    • 34
    • 1
    Polyclonal
    Conjugué
    • 12
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp GCAP1 est non-conjugé
    Application
    • 29
    • 17
    • 13
    • 13
    • 10
    • 5
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
    Immunogène
    This GCAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 160-191 amino acids from the C-terminal region of human GCAP1.
    Isotype
    Ig Fraction
    Top Product
    Discover our top product GUCA1A Anticorps primaire
  • Indications d'application
    For WB starting dilution is: 1:1000

    For IHC-P starting dilution is: 1:50~100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Antigène
    GCAP1 (GUCA1A) (Guanylate Cyclase Activator 1A (Retina) (GUCA1A))
    Autre désignation
    GCAP1 (GUCA1A Produits)
    Synonymes
    anticorps C6orf131, anticorps COD3, anticorps CORD14, anticorps GCAP, anticorps GCAP1, anticorps GUCA, anticorps GUCA1, anticorps dJ139D8.6, anticorps MGC84170, anticorps GUCA1A, anticorps guca1a, anticorps MGC146317, anticorps GC-A, anticorps Gcap1, anticorps Guca1, anticorps mGCAP1, anticorps gcap1, anticorps guanylate cyclase activator 1A, anticorps guanylate cyclase activator 1A L homeolog, anticorps guanylate cyclase activator 1A (retina), anticorps guanylate cyclase activator 1a (retina), anticorps GUCA1A, anticorps Guca1a, anticorps guca1a.L, anticorps guca1a
    Sujet
    Guanylate cyclase-activating protein is a l Ca(2+)-binding protein that upregulates synthesis of cGMP in photoreceptors. The known mammalian GCAPs are more than 90 % similar, consisting of 201 to 205 amino acids, and containing 3 identically conserved Ca(2+)-binding sites. The GUCA1A gene, also termed GCAP1, is transcribed into a single 1.7-kb mRNA species detectable only in the retina. In a 4-generation British family with typical clinical features of autosomal dominant cone dystrophy a tyr99-to-cys mutation) in the GUCA1A gene has been identified. Another family with a pro50-to-leu mutation in GUCA1A demonstrated phenotypic variability ranging from mild photophobia to rod-cone dystrophy. The mutant protein could activate guanylate cyclase 1 (GUCY2D) and displayed similar calcium sensitivity to wildtype protein. However, there was a marked increase in the susceptibility to protease degradation and a reduction in the thermal stability of the pro50-to-leu mutation, which may depress cellular concentration and thereby contribute to retinal cell mortality.
    Poids moléculaire
    23 kDa
    ID gène
    2978
    UniProt
    P43080
    Pathways
    Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction
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