PRDM6 anticorps (N-Term)

N° du produit ABIN5531881

Détail du produit anti-PRDM6 anticorps

Antigène: PRDM6 (PR Domain Containing 6 (PRDM6))

Épitope: AA 44-72, N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PRDM6 est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This PRDM6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 44-72 amino acids from the N-terminal region of human PRDM6.

Isotype: Ig Fraction

Information d'application

Indications d'application: For WB starting dilution is: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.35 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur PRDM6

Antigène: PRDM6 (PR Domain Containing 6 (PRDM6))

Autre désignation: PRDM6 (PRDM6 Produits)

Synonymes: anticorps Gm92, anticorps PRISM, anticorps RGD1559594, anticorps PRDM6, anticorps PR/SET domain 6, anticorps PR domain containing 6, anticorps putative histone-lysine N-methyltransferase PRDM6, anticorps PRDM6, anticorps Prdm6, anticorps LOC100354345, anticorps prdm6

Sujet: Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells. Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a. According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro. 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression (By similarity).

Poids moléculaire: 64 kDa

ID gène: 93166

UniProt: Q9NQX0

Pathways: Regulation of Muscle Cell Differentiation