SIGLEC6 anticorps (C-Term)

N° du produit ABIN5534686

Détail du produit anti-SIGLEC6 anticorps

Antigène: SIGLEC6 (Sialic Acid Binding Ig-Like Lectin 6 (SIGLEC6))

Épitope: AA 381-412, C-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SIGLEC6 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This SIGLEC6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 381-412 amino acids from the C-terminal region of human SIGLEC6.

Isotype: Ig Fraction

Information d'application

Indications d'application: For IHC-P starting dilution is: 1:50~100

For WB starting dilution is: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur SIGLEC6

Antigène: SIGLEC6 (Sialic Acid Binding Ig-Like Lectin 6 (SIGLEC6))

Autre désignation: SIGLEC6 (SIGLEC6 Produits)

Synonymes: anticorps SIGLEC6, anticorps CD327, anticorps CD33L, anticorps CD33L1, anticorps CD33L2, anticorps CDW327, anticorps OBBP1, anticorps sialic acid binding Ig like lectin 6, anticorps SIGLEC6

Sujet: SIGLEC6 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells by binding to alpha2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. SIGLEC6, which interacts with LEP, is expressed at high levels in placenta (cyto-and syncytiotrophoblastic cells) and at lower levels in spleen, peripheral blood leukocytes (predominantly B-cells) and small intestine. It contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in downmodulation of cellular responses. The phosphorylated ITIM motif binds to the SH2 domain of PTPN6/SHP-1. The gene for SIGLEC6 belongs to the immunoglobulin superfamily.

Poids moléculaire: 50 kDa

ID gène: 946

UniProt: O43699