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SIGLEC8 anticorps (C-Term)

SIGLEC8 Reactivité: Humain, Souris WB, IHC (p) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN5534688
  • Antigène Voir toutes SIGLEC8 Anticorps
    SIGLEC8 (Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8))
    Épitope
    • 8
    • 7
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 373-406, C-Term
    Reactivité
    • 42
    • 5
    • 2
    Humain, Souris
    Hôte
    • 31
    • 10
    • 1
    Lapin
    Clonalité
    • 33
    • 9
    Polyclonal
    Conjugué
    • 22
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp SIGLEC8 est non-conjugé
    Application
    • 31
    • 20
    • 19
    • 5
    • 5
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
    Immunogène
    This SIGLEC8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 373-406 amino acids from the C-terminal region of human SIGLEC8.
    Isotype
    Ig Fraction
    Top Product
    Discover our top product SIGLEC8 Anticorps primaire
  • Indications d'application
    For WB starting dilution is: 1:1000

    For IHC-P starting dilution is: 1:50~100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1.67 mg/mL
    Buffer
    Supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Antigène
    SIGLEC8 (Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8))
    Autre désignation
    SIGLEC8 (SIGLEC8 Produits)
    Synonymes
    anticorps SAF2, anticorps SIGLEC-8, anticorps SIGLEC8L, anticorps SIGLEC8, anticorps sialic acid binding Ig like lectin 8, anticorps sialic acid-binding Ig-like lectin 8, anticorps SIGLEC8, anticorps LOC506364
    Sujet
    SIGLEC8 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. It preferentially binds to alpha2,3-linked sialic acid. and also binds to alpha2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. SIGLEC8 is expressed specifically on eosinophils. The protein contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in downmodulation of cellular responses. The phosphorylated ITIM motif binds to the SH2 domain of PTPN6/SHP-1. The SIGLEC8 gene belongs to the immunoglobulin superfamily.
    Poids moléculaire
    54 kDa
    ID gène
    27181
    UniProt
    Q9NYZ4
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