USP20 anticorps (AA 310-339)

N° du produit ABIN5534787

Détail du produit anti-USP20 anticorps

Antigène: USP20 (Ubiquitin Specific Peptidase 20 (USP20))

Épitope: AA 310-339

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp USP20 est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This USP20 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 310-339 amino acids from the Central region of human USP20.

Isotype: Ig Fraction

Information d'application

Indications d'application: For WB starting dilution is: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur USP20

Antigène: USP20 (Ubiquitin Specific Peptidase 20 (USP20))

Autre désignation: USP20 (USP20 Produits)

Synonymes: anticorps USP20, anticorps vdu2, anticorps lsfr3a, anticorps LSFR3A, anticorps VDU2, anticorps hVDU2, anticorps 1700055M05Rik, anticorps AI467231, anticorps Vdu2, anticorps im:7151955, anticorps zgc:63661, anticorps universal stress protein, anticorps ubiquitin specific peptidase 20, anticorps ubiquitin specific peptidase 20 L homeolog, anticorps RR_RS15875, anticorps USP20, anticorps usp20, anticorps Usp20, anticorps usp20.L

Sujet: Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both 'Lys-48'-and 'Lys-63'-linked polyubiquitin chains.

Poids moléculaire: 102 kDa

ID gène: 10868

UniProt: Q9Y2K6

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling