Deoxyuridine Triphosphatase (DUT) (AA 170-198), (C-Term) anticorps

N° du produit ABIN5534888

Détail du produit

Antigène: Deoxyuridine Triphosphatase (DUT)

Épitope: AA 170-198, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This DUT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 170-198 amino acids from the C-terminal region of human DUT.

Isotype: Ig Fraction

Information d'application

Indications d'application: For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:10~50

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détail du antigène

Antigène: Deoxyuridine Triphosphatase (DUT)

Autre désignation: DUT (DUT Produits)

Synonymes: anticorps BcDNA:LD08534, anticorps CG4584, anticorps Dmel\\CG4584, anticorps LD08534, anticorps UTPase, anticorps anon-SAGE:Wang-077, anticorps dUTPase, anticorps Tb07.27E10.390, anticorps dutpase, anticorps 5031412I06Rik, anticorps 5133400F09Rik, anticorps D2Bwg0749e, anticorps Dutp, anticorps PIP4, anticorps deoxyuridine triphosphatase, anticorps Deoxyuridine triphosphatase, anticorps dUTPase; ORF54; similar to EBV BLLF3, CMV UL72, HSV UL50, anticorps involved in nucleotide metabolism, anticorps tegument protein, anticorps dUTPase, anticorps deoxyuridine triphosphatase L homeolog, anticorps DUT, anticorps dUTPase, anticorps P18, anticorps AlHV1gp51, anticorps UL50, anticorps HVT058, anticorps ORF9, anticorps ORF8, anticorps U45, anticorps GAMMAHV.ORF54, anticorps Tc00.1047053509151.130, anticorps Tc00.1047053508175.160, anticorps Tb927.7.5160, anticorps dut.L, anticorps Dut

Classe de substances: Viral Protein

Sujet: This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19.

Poids moléculaire: 27 kDa

ID gène: 1854

UniProt: P33316