IRS4 anticorps (AA 633-647)

N° du produit ABIN5539610

Détail du produit anti-IRS4 anticorps

Antigène: IRS4 (Insulin Receptor Substrate 4 (IRS4))

Épitope: AA 633-647

Reactivité: Souris

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp IRS4 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Fonction: Irs4 (mouse aa633-647)

Séquence: DRGTKERKEA KEVRD

Réactivité croisée: Souris, Rat

Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Classe de qualité: Verified

Isotype: IgG

Information d'application

Indications d'application:

Western Blot: Approx 150 kDa band observed in Mouse Heart lysates (calculated MW of 130 kDa according to NP_034702.2). The observed molecular weight corresponds to earlier findings in literature with different antibodies (Schreyer et al, jEndocrinology. 20

Peptide ELISA: antibody detection limit dilution 1:128000.

Commentaires:

Immunofluorescence: This product has been successfully used in IF on Mouse: Harriet M Jackson et al, BMC Genomics. 2013 Nov 25,14:831. PMID: 24274089.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Supplied at 0.5 mg/mL in Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Minimize freezing and thawing.

Stock: -20 °C

Stockage commentaire: Aliquot and store at -20°C, with minimal freeze/thawing. A working aliquot may be refrigerated at 4°C for a few weeks and still remain viable.

Références pour anticorps anti-IRS4 (ABIN5539610)

Ikink, Boer, Bakker, Hilkens: "IRS4 induces mammary tumorigenesis and confers resistance to HER2-targeted therapy through constitutive PI3K/AKT-pathway hyperactivation." dans: Nature communications, Vol. 7, pp. 13567, (2018) (PubMed).

Détails sur IRS4

Antigène: IRS4 (Insulin Receptor Substrate 4 (IRS4))

Autre désignation: Irs4 (IRS4 Produits)

Synonymes: anticorps IRS4, anticorps irs-4, anticorps py160, anticorps IRS-4, anticorps PY160, anticorps irs2, anticorps irs2-a, anticorps insulin receptor substrate 4, anticorps insulin receptor substrate 4 S homeolog, anticorps IRS4, anticorps irs4, anticorps Irs4, anticorps irs4.S

Sujet: Irs4, insulin receptor substrate 4, IRS-4, RP23-415G1.3, phosphoprotein of 160 kDa, pp160

ID gène: 16370, 315350

NCBI Accession: NP_034702