NMDA 1 Receptor anticorps (pSer890)

N° du produit ABIN5540835

Détail du produit anti-NMDA 1 Receptor anticorps

Antigène: NMDA 1 Receptor (NMDA R1) (NMDA Receptor 1 (NMDA R1))

Épitope: pSer890

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NMDA 1 Receptor est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: The antibody detects endogenous levels of NMDAR1 only when phosphorylated at serine 890.

Purification: Affinity chromatography using epitope-specific peptide

Immunogène: Peptide sequence around phosphorylation site of Serine 890(A-S-S(p)-F-K) derived from Human NMDAR1 (KLH-conjugated)

Information d'application

Indications d'application: Immunohistochemistry on paraffin sections: 1:50~1:100. Immunofluorescence: 1:100~1:200.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur NMDA 1 Receptor

Antigène: NMDA 1 Receptor (NMDA R1) (NMDA Receptor 1 (NMDA R1))

Autre désignation: nmda receptor 1 (NMDA R1 Produits)

Synonymes: anticorps CG2902, anticorps DMNMDAR1, anticorps DNMDAR-I, anticorps DNmdar, anticorps DmelNmdar1, anticorps Dmel\\CG2902, anticorps DrNR1, anticorps NMDA, anticorps NMDA R1, anticorps NMDAR1, anticorps NMdar1, anticorps NR1, anticorps NRI, anticorps Nmdar, anticorps dNR1, anticorps dnmdar-I, anticorps nmr, anticorps NMDA receptor 1, anticorps Nmdar1

Sujet: NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and AMPA receptors. NMDA receptors consist of NR1 subunits combined with one or more NR2 (A-D) or NR3 (A-B) subunits. The ligand-gated channel is permeable to cations including Ca2+, and at resting membrane potentials NMDA receptors are inactive due to a voltage-dependent blockade of the channel pore by Mg2+. NMDA receptor activation, which requires binding of glutamate and glycine, leads to an influx of Ca2+ into the postsynaptic region where it activates several signaling cascades, including pathways leading to the induction of long-term potentiation (LTP) and depression (LTD). NMDA receptors have a critical role in excitatory synaptic transmission and plasticity in the CNS. They govern a range of physiological conditions including neurological disorders caused by excitotoxic neuronal injury, psychiatric disorders and neuropathic pain syndromes.

UniProt: Q05586