CEACAM20
Reactivité: Humain
Hôte: Lapin
Polyclonal
Alexa Fluor 555
Indications d'application
Cell based ELISA with intakt, transiently transfected cells: 1/200-1/400. ELISA (capture): With clone HD-6G4-A5 as detection antibody. Flow cytometry: 1.2 μg/10e6 cells. Immunofluorescence: 1 μg/10e6 cells.
Restrictions
For Research Use only
Format
Liquid
Buffer
Phosphate buffered saline, pH 7.2
Stock
4 °C,-20 °C
Stockage commentaire
Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
CEA-related cell adhesion molecule 20 (CEACAM20) belongs to the carcinoembryonic antigen (CEA) gene family (1). It encodes a putative glycoprotein which is membrane-bound via a transmembrane domain. The CEACAM20 protein contains a single N domain followed by 4 immunoglobulin-like A (A1, A2) and B (B1, B2) domains. Expression of CEACAM20 can be found in tissues of prostate, testis, duodenum and small intestine with highest expression in prostate. The function of CEACAM family members varies widely: they function as cell adhesion molecules, tumor suppressors, regulators of lymphocyte and dendritic cell activation, receptors of Neisseria species and other bacteria. High expression of CEACAM20 in tissue of prostate carcinoma and in prostate carcinoma cell lines suggest that CEACAM20 can be used as a tumor marker.