TEP1 anticorps (N-Term)

N° du produit ABIN5541415

Détail du produit anti-TEP1 anticorps

Antigène: TEP1 (Telomerase-Associated Protein 1 (TEP1))

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TEP1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: Species: Human, Mouse and Rat.

Purification: Immunoaffinity Chromatography.

Immunogène: Synthetic Peptide corresponding to 20 Amino Acid peptide from near the amino terminus of human TP1.

Information d'application

Indications d'application: Immunohistochemistry on Paraffin Sections (5 μg/mL). Western Blot.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Phosphate Buffered Saline PBS containing 0.02 % Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Dilute only prior to immediate use. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur TEP1

Antigène: TEP1 (Telomerase-Associated Protein 1 (TEP1))

Autre désignation: tep1,tlp1 (TEP1 Produits)

Synonymes: anticorps TLP1, anticorps TP1, anticorps TROVE1, anticorps VAULT2, anticorps p240, anticorps Tp1, anticorps Tlp1, anticorps telomerase associated protein 1, anticorps TEP1, anticorps Tep1

Sujet: Telomerase is an RNA-dependent DNA polymerase that uses an RNA component to add telomeric repeat sequences at the ends of chromosomes. Besides the RNA component which serves as the template that specifies the telomeric repeat, the telomerase complex contains a reverse transcriptase protein (TRT) and various accessory proteins including the telomerase-associated protein 1 (TEP1). Telomerase activity is low in most somatic cells, causing the gradual shortening of telomeres which can ultimately lead to telomere fusion and cell death. High levels of telomerase activity are widely seen in cancerous cells and while recent experiments have suggested that telomerase may be a viable target in cancer therapy, expression levels of TEP1 do not correlate with malignancy. At least two isoforms of TP1 are known to exist.

UniProt: Q99973

Pathways: Inositol Metabolic Process, Synaptic Membrane, Regulation of Cell Size, Autophagy, Platelet-derived growth Factor Receptor Signaling, Signaling of Hepatocyte Growth Factor Receptor