BIN1 anticorps (AA 189-398)
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- Antigène Voir toutes BIN1 Anticorps
- BIN1 (Bridging Integrator 1 (BIN1))
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Épitope
- AA 189-398
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp BIN1 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Flow Cytometry (FACS)
- Fonction
- BIN1 Antibody
- Purification
- Purified antibody
- Immunogène
- Purified recombinant fragment of human BIN1 (AA: 189-398) expressed in E. Coli.
- Clone
- 3B6A4
- Isotype
- IgG2b
- Top Product
- Discover our top product BIN1 Anticorps primaire
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- Indications d'application
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ELISA: 1/10000
FCM: 1/200 - 1/400
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Purified antibody in PBS with 0.05 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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- Antigène
- BIN1 (Bridging Integrator 1 (BIN1))
- Autre désignation
- BIN1 (BIN1 Produits)
- Sujet
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Description: This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in several transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.
Aliases: AMPH2, AMPHL, SH3P9
- Poids moléculaire
- 64.7kDa
- ID gène
- 274
- HGNC
- 274
- UniProt
- O00499
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