POMC anticorps (AA 1-150)

N° du produit ABIN5542293

Détail du produit anti-POMC anticorps

Antigène: POMC (Proopiomelanocortin (POMC))

Épitope: AA 1-150

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp POMC est non-conjugé

Application: ELISA, Immunocytochemistry (ICC)

Fonction: POMC Antibody

Purification: Purified antibody

Immunogène: Purified recombinant fragment of human POMC (AA: 1-150) expressed in E. Coli.

Clone: 6D2B5

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Détails sur POMC

Antigène: POMC (Proopiomelanocortin (POMC))

Autre désignation: POMC (POMC Produits)

Synonymes: anticorps MSH, anticorps ACTH, anticorps pomc, anticorps SI:bZ36D5.1, anticorps SI:bZ36D5.4, anticorps si:bz36d5.2, anticorps BE, anticorps Beta-LPH, anticorps Clip, anticorps Gamma-LPH, anticorps Npp, anticorps Pomc-1, anticorps Pomc1, anticorps alpha-MSH, anticorps alphaMSH, anticorps beta-MSH, anticorps gamma-MSH, anticorps CLIP, anticorps LPH, anticorps NPP, anticorps POC, anticorps Pomc2, anticorps proopiomelanocortin a, anticorps pro-opiomelanocortin-alpha, anticorps proopiomelanocortin, anticorps pomca, anticorps Pomc, anticorps POMC

Sujet:

Description: This gene encodes a preproprotein that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the preproprotein and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used, adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. The antimicrobial melanotropin alpha peptide exhibits antibacterial and antifungal activity. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described.

Aliases: LPH, MSH, NPP, POC, ACTH, CLIP

Poids moléculaire: 29.4kDa

ID gène: 5443

HGNC: 5443

UniProt: P01189

Pathways: Metabolism of Steroid Hormones and Vitamin D, Peptide Hormone Metabolism, Hormone Activity, Feeding Behaviour