DNMT3L anticorps (AA 147-386)
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- Antigène Voir toutes DNMT3L (TRDMT1) Anticorps
- DNMT3L (TRDMT1) (DNA (Cytosine-5-)-Methyltransferase 3 Like (TRDMT1))
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Épitope
- AA 147-386
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp DNMT3L est non-conjugé
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Application
- ELISA, Flow Cytometry (FACS)
- Fonction
- DNMT3L Antibody
- Purification
- Purified antibody
- Immunogène
- Purified recombinant fragment of human DNMT3L (AA: 147-386) expressed in E. Coli.
- Clone
- 2D10H11
- Isotype
- IgG1
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- Indications d'application
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ELISA: 1/10000
FCM: 1/200 - 1/400
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Purified antibody in PBS with 0.05 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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- Antigène
- DNMT3L (TRDMT1) (DNA (Cytosine-5-)-Methyltransferase 3 Like (TRDMT1))
- Autre désignation
- DNMT3L (TRDMT1 Produits)
- Synonymes
- anticorps DNMT3L, anticorps D6Ertd14e, anticorps ecat7, anticorps DNA methyltransferase 3 like, anticorps DNA (cytosine-5-)-methyltransferase 3-like, anticorps DNMT3L, anticorps Dnmt3l
- Sujet
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CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases, but is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, it does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
- Poids moléculaire
- 43.6kDa
- ID gène
- 29947
- HGNC
- 29947
- UniProt
- Q9UJW3
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