MAP2K3 anticorps (AA 1-138)

N° du produit ABIN5542528

Détail du produit anti-MAP2K3 anticorps

Antigène: MAP2K3 (Mitogen-Activated Protein Kinase Kinase 3 (MAP2K3))

Épitope: AA 1-138

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MAP2K3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC), Flow Cytometry (FACS)

Purification: purified

Immunogène: Purified recombinant fragment of human MAP2K3 (AA: 1-138) expressed in E. coli.

Clone: 2E12D11

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: 1:200 - 1:1000, FCM: 1:200 - 1:400

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: 4°C, -20°C for long term storage

Détails sur MAP2K3

Antigène: MAP2K3 (Mitogen-Activated Protein Kinase Kinase 3 (MAP2K3))

Autre désignation: MAP2K3 (MAP2K3 Produits)

Synonymes: anticorps MAPKK3, anticorps MEK3, anticorps MKK3, anticorps PRKMK3, anticorps SAPKK-2, anticorps SAPKK2, anticorps AW212142, anticorps Prkmk3, anticorps mMKK3b, anticorps Mkk3, anticorps mitogen-activated protein kinase kinase 3, anticorps mitogen activated protein kinase kinase 3, anticorps MAP kinase activator XMEK3, anticorps MAP2K3, anticorps Map2k3, anticorps map2k3

Sujet:

Description: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene.,

Aliases: MEK3, MKK3, MAPKK3, PRKMK3, SAPKK2, SAPKK-2

Poids moléculaire: 39.3 kDa

ID gène: 5606

HGNC: 5606

Pathways: Signalisation MAPK, Signalisation TLR, Activation of Innate immune Response, Toll-Like Receptors Cascades, Autophagy, Signaling Events mediated by VEGFR1 and VEGFR2