ERBB4 anticorps (AA 1159-1308)

N° du produit ABIN5542589

Détail du produit anti-ERBB4 anticorps

Antigène: ERBB4 (V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4))

Épitope: AA 1159-1308

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ERBB4 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Fonction: ERBB4 Antibody

Purification: Purified antibody

Immunogène: Purified recombinant fragment of human ERBB4 (AA: 1159-1308) expressed in E. Coli.

Clone: 5G6B4

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Détails sur ERBB4

Antigène: ERBB4 (V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4))

Autre désignation: ERBB4 (ERBB4 Produits)

Synonymes: anticorps erbb4, anticorps si:ch211-227n20.1, anticorps Her4, anticorps c-erbB-4, anticorps HER4, anticorps p180erbB4, anticorps erb-b2 receptor tyrosine kinase 4, anticorps erb-b2 receptor tyrosine kinase 4a, anticorps v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian), anticorps erb-b2 receptor tyrosine kinase 4 L homeolog, anticorps receptor tyrosine-protein kinase ErbB-4, anticorps ERBB4, anticorps erbb4a, anticorps erbb4, anticorps erbb4.L, anticorps Tsp_13582, anticorps Erbb4

Sujet:

Description: This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described, however, not all variants have been fully characterized.

Aliases: HER4, ALS19, p180erbB4

Poids moléculaire: 146.8kDa

ID gène: 2066

HGNC: 2066

UniProt: Q15303

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway