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IRF1 anticorps

IRF1 Reactivité: Humain, Souris WB, IF (p), IHC (p), FACS, IF (cc) Hôte: Lapin Monoclonal 3G7 unconjugated
N° du produit ABIN5557374
  • Antigène Voir toutes IRF1 Anticorps
    IRF1 (Interferon Regulatory Factor 1 (IRF1))
    Reactivité
    • 90
    • 52
    • 35
    • 9
    • 9
    • 8
    • 8
    • 7
    • 6
    • 5
    • 4
    • 1
    • 1
    • 1
    Humain, Souris
    Hôte
    • 93
    • 7
    • 1
    • 1
    Lapin
    Clonalité
    • 88
    • 14
    Monoclonal
    Conjugué
    • 47
    • 12
    • 9
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp IRF1 est non-conjugé
    Application
    • 86
    • 34
    • 15
    • 11
    • 9
    • 6
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc))
     Réactivité croisée
    Humain, Souris
    Purification
    Purified by Protein A.
    Immunogène
    Recombinant human IRF1 protein, around C-terminal 100aa.
    Clone
    3G7
    Isotype
    IgG
    Top Product
    Discover our top product IRF1 Anticorps primaire
  • Indications d'application
    WB 1:300-5000
    FCM 1:20-100
    IHC-P 1:200-400
    IF(IHC-P) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Date de péremption
    12 months
  • Antigène
    IRF1 (Interferon Regulatory Factor 1 (IRF1))
    Autre désignation
    IRF1 (IRF1 Produits)
    Synonymes
    anticorps irf1, anticorps zgc:136945, anticorps IRF1, anticorps irf11, anticorps zgc:103566, anticorps IRF-1, anticorps MAR, anticorps AU020929, anticorps Irf-1, anticorps interferon regulatory factor 1, anticorps interferon regulatory factor 1a, anticorps interferon regulatory factor 1b, anticorps IRF1, anticorps irf1a, anticorps irf1b, anticorps Irf1
    Sujet

    Synonyms: Interferon regulatory factor 1, IRF1

    Background: Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. These include the regulation of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage. Stimulates both innate and acquired immune responses through the activation of specific target genes and can act as a transcriptional activator and repressor regulating target genes by binding to an interferon-stimulated response element (ISRE) in their promoters. Its target genes for transcriptional activation activity include: genes involved in anti-viral response, such as IFN-alpha/beta, DDX58/RIG-I, TNFSF10/TRAIL, OAS1/2, PIAS1/GBP, EIF2AK2/PKR and RSAD2/viperin, antibacterial response, such as NOS2/INOS, anti-proliferative response, such as p53/TP53, LOX and CDKN1A, apoptosis, such as BBC3/PUMA, CASP1, CASP7 and CASP8, immune response, such as IL7, IL12A/B and IL15, PTGS2/COX2 and CYBB, DNA damage responses and DNA repair, such as POLQ/POLH, MHC class I expression, such as TAP1, PSMB9/LMP2, PSME1/PA28A, PSME2/PA28B and B2M and MHC class II expression, such as CIITA. Represses genes involved in anti-proliferative response, such as BIRC5/survivin, CCNB1, CCNE1, CDK1, CDK2 and CDK4 and in immune response, such as FOXP3, IL4, ANXA2 and TLR4. Stimulates p53/TP53-dependent transcription through enhanced recruitment of EP300 leading to increased acetylation of p53/TP53. Plays an important role in immune response directly affecting NK maturation and activity, macrophage production of IL12, Th1 development and maturation of CD8+ T-cells. Also implicated in the differentiation and maturation of dendritic cells and in the suppression of regulatory T (Treg) cells development. Acts as a tumor suppressor and plays a role not only in antagonism of tumor cell growth but also in stimulating an immune response against tumor cells.

    ID gène
    3659
    UniProt
    P10914
    Pathways
    Interferon-gamma Pathway, Response to Growth Hormone Stimulus, Positive Regulation of Immune Effector Process, Hepatitis C, Autophagy
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