Desmoplakin anticorps (C-Term, pSer2849)

N° du produit ABIN5596788

Détail du produit anti-Desmoplakin anticorps

Antigène: Desmoplakin (DSP)

Épitope: C-Term, pSer2849

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Desmoplakin est non-conjugé

Application: ELISA, Western Blotting (WB)

Réactivité croisée (Details): A BLAST analysis was used to suggest cross-reactivity with mouse and human based on 100% sequence homology. Cross-reactivity with Desmoplakin pS2849 from other sources has not been determined.

Purification: Anti-Desmoplakin pS2849 was affinity purified from monospecific antiserum by immunoaffinity chromatography and is directed against the phosphorylated form of the S2849 human residue.

Immunogène:

Immunogen: Anti-Desmoplakin pS2849 affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide near the C-terminus of human Desmoplakin protein.

Immunogen Type: Peptide

Isotype: IgG

Information d'application

Indications d'application:

Application Note: Anti-Desmoplakin pS2849 antibody is useful for ELISA, Immunohistochemistry, and Western Blot. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately ~331 kDa corresponding to the appropriate cell lysate or extract.

Western Blot Dilution: 1 μg/mL

ELISA Dilution: 1: 10,000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.67 mg/mL

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: 30 % Glycerol

Stock: 4 °C,-20 °C

Stockage commentaire: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Date de péremption: 12 months

Détails sur Desmoplakin

Antigène: Desmoplakin (DSP)

Autre désignation: Desmoplakin (DSP Produits)

Synonymes: anticorps DP, anticorps DPI, anticorps DPII, anticorps DSP, anticorps dpi, anticorps dpii, anticorps 2300002E22Rik, anticorps 5730453H04Rik, anticorps AA407887, anticorps AA407888, anticorps AW109828, anticorps im:6911953, anticorps sb:cb570, anticorps wu:fc17a08, anticorps wu:fk73d01, anticorps desmoplakin, anticorps Desmoplakin, anticorps ORF113, anticorps desmoplakin a, anticorps ORF112 DESMOPLAKIN, anticorps orf102, anticorps orf91; similar to Cydia pomonella granulovirus orf112, anticorps ORF62, anticorps ORF-66, anticorps ORF57, anticorps agip105, anticorps similar to XcORF133; similar to HaGV desmoplakin, anticorps desmoplakin L homeolog, anticorps ORF96, anticorps DSP, anticorps PhopGV104, anticorps ORF-59 desmoplakin, anticorps desmop, anticorps Dsp, anticorps dsp, anticorps desmoplakin, anticorps dspa, anticorps orf112 desmoplakin, anticorps ClgVgp102, anticorps COGV_gp091, anticorps APNV_p087, anticorps CBNV_gp066, anticorps EONV_gp057, anticorps OLNV_gp066, anticorps AgipMNPV_gp105, anticorps HaMNV_gp106, anticorps EupsNPV_gp065, anticorps PsunGV_gp139, anticorps dsp.L, anticorps ClanGV_gp096

Sujet:

Synonyms: 250/210 kDa paraneoplastic pemphigus antigen, DSP, DPI, DPII

Background: Desmoplakin pS2849 is high molecular weight protein of desmosomes. It is a member of the plakin or cytolinker family and is involved in the organization of the desmosomal cadherin-plakoglobin complexes into plasma membrane domains in the anchoring of intermediate filaments to the desmosomes. The phosphorylation theoretically affects its association with epidermal, simple cytokeratins and VIM intermediate filaments. Defects in DSP are the cause of keratosis palmoplantaris striata II, Carvajal syndrome, and arrhythmogenic right ventricular cardiomyopathy 8. Anti-Desmoplakin pS2849 Antibody is ideal for researchers interested in Cell Structure research.

Gene Name: DSP

Pathways: Cell-Cell Junction Organization