BTRC anticorps (AA 24-151)

N° du produit ABIN5611131

Détail du produit anti-BTRC anticorps

Antigène: BTRC (beta-Transducin Repeat Containing (BTRC))

Épitope: AA 24-151

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp BTRC est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Fonction: BTRC Antibody

Purification: Purified antibody

Immunogène: Purified recombinant fragment of human BTRC (AA: 24-151) expressed in E. Coli.

Clone: 4C5D8

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Détails sur BTRC

Antigène: BTRC (beta-Transducin Repeat Containing (BTRC))

Autre désignation: BTRC (BTRC Produits)

Synonymes: anticorps BTRC, anticorps Beta-TrCP, anticorps betaTrCP, anticorps btrcp, anticorps btrcp1, anticorps fbw1a, anticorps fbxw1, anticorps fbxw1a, anticorps fwd1, anticorps btrc, anticorps beta-TrCP, anticorps BETA-TRCP, anticorps FBW1A, anticorps FBXW1, anticorps FBXW1A, anticorps FWD1, anticorps bTrCP, anticorps bTrCP1, anticorps beta-TrCP1, anticorps btrc-a, anticorps Beta-Trcp1, anticorps Fbw1a, anticorps HOS, anticorps Slimb, anticorps b-TrCP, anticorps mKIAA4123, anticorps beta-transducin repeat containing E3 ubiquitin protein ligase, anticorps beta-transducin repeat containing, anticorps beta-TrCP, anticorps beta-transducin repeat containing E3 ubiquitin protein ligase S homeolog, anticorps beta-transducin repeat containing protein, anticorps BTRC, anticorps btrc, anticorps LOC100634006, anticorps Btrc, anticorps btrc.S

Sujet:

Description: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class, in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6.

Aliases: FWD1, FBW1A, FBXW1, bTrCP, FBXW1A, bTrCP1, betaTrCP, BETA-TRCP

Poids moléculaire: 68.9kDa

ID gène: 8945

HGNC: 8945

UniProt: Q9Y297

Pathways: Cycle Cellulaire, Signalisation Hedgehog