GRM2 anticorps (AA 414-558)

N° du produit ABIN5611158

Détail du produit anti-GRM2 anticorps

Antigène: GRM2 (Glutamate Receptor, Metabotropic 2 (GRM2))

Épitope: AA 414-558

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp GRM2 est non-conjugé

Application: ELISA, Flow Cytometry (FACS)

Fonction: GRM2 Antibody

Purification: Purified antibody

Immunogène: Purified recombinant fragment of human GRM2 (AA: 414-558) expressed in E. Coli.

Clone: 4A10B9

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Détails sur GRM2

Antigène: GRM2 (Glutamate Receptor, Metabotropic 2 (GRM2))

Autre désignation: GRM2 (GRM2 Produits)

Synonymes: anticorps GLUR2, anticorps GPRC1B, anticorps MGLUR2, anticorps mGlu2, anticorps 4930441L02Rik, anticorps Gprc1b, anticorps mGluR2, anticorps mGluR7, anticorps glutamate metabotropic receptor 2, anticorps glutamate receptor, metabotropic 2, anticorps GRM2, anticorps Grm2

Sujet:

Description: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene.

Aliases: GLUR2, mGlu2, GPRC1B, MGLUR2

Poids moléculaire: 95.6kDa

ID gène: 2912

HGNC: 2912

UniProt: Q14416

Pathways: cAMP Metabolic Process, Dicarboxylic Acid Transport