GRM8 anticorps (AA 440-583)

N° du produit ABIN5611162

Détail du produit anti-GRM8 anticorps

Antigène: GRM8 (Glutamate Receptor, Metabotropic 8 (GRM8))

Épitope: AA 440-583

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp GRM8 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Fonction: GRM8 Antibody

Purification: Purified antibody

Immunogène: Purified recombinant fragment of human GRM8 (AA: 440-583) expressed in E. Coli.

Clone: 4C1C1

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Détails sur GRM8

Antigène: GRM8 (Glutamate Receptor, Metabotropic 8 (GRM8))

Autre désignation: GRM8 (GRM8 Produits)

Sujet:

Description: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Aliases: GLUR8, mGlu8, GPRC1H, MGLUR8

Poids moléculaire: 101.7kDa

ID gène: 2918

HGNC: 2918

UniProt: O00222

Pathways: cAMP Metabolic Process, Synaptic Membrane