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GRM8 anticorps (AA 440-583)

GRM8 Reactivité: Humain WB, ELISA, FACS Hôte: Souris Monoclonal 4C1C1 unconjugated
N° du produit ABIN5611162
  • Antigène Voir toutes GRM8 Anticorps
    GRM8 (Glutamate Receptor, Metabotropic 8 (GRM8))
    Épitope
    • 8
    • 6
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 440-583
    Reactivité
    • 30
    • 23
    • 14
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 28
    • 2
    Souris
    Clonalité
    • 29
    • 1
    Monoclonal
    Conjugué
    • 18
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp GRM8 est non-conjugé
    Application
    • 18
    • 12
    • 8
    • 4
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Flow Cytometry (FACS)
    Fonction
    GRM8 Antibody
    Purification
    Purified antibody
    Immunogène
    Purified recombinant fragment of human GRM8 (AA: 440-583) expressed in E. Coli.
    Clone
    4C1C1
    Isotype
    IgG1
  • Indications d'application

    ELISA: 1/10000

    FCM: 1/200 - 1/400

    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified antibody in PBS with 0.05 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Antigène
    GRM8 (Glutamate Receptor, Metabotropic 8 (GRM8))
    Autre désignation
    GRM8 (GRM8 Produits)
    Sujet

    Description: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

    Aliases: GLUR8, mGlu8, GPRC1H, MGLUR8

    Poids moléculaire
    101.7kDa
    ID gène
    2918
    HGNC
    2918
    UniProt
    O00222
    Pathways
    cAMP Metabolic Process, Synaptic Membrane
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