GRM8 anticorps (AA 440-583)
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- Antigène Voir toutes GRM8 Anticorps
- GRM8 (Glutamate Receptor, Metabotropic 8 (GRM8))
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Épitope
- AA 440-583
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp GRM8 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Flow Cytometry (FACS)
- Fonction
- GRM8 Antibody
- Purification
- Purified antibody
- Immunogène
- Purified recombinant fragment of human GRM8 (AA: 440-583) expressed in E. Coli.
- Clone
- 4C1C1
- Isotype
- IgG1
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- Indications d'application
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ELISA: 1/10000
FCM: 1/200 - 1/400
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Purified antibody in PBS with 0.05 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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- Antigène
- GRM8 (Glutamate Receptor, Metabotropic 8 (GRM8))
- Autre désignation
- GRM8 (GRM8 Produits)
- Synonymes
- anticorps mGluR8, anticorps GRM8, anticorps MGLUR8, anticorps GLUR8, anticorps GPRC1H, anticorps mGlu8, anticorps A230002O04, anticorps Gprc1h, anticorps Glur8, anticorps Mglur8, anticorps mGluR8b, anticorps mGlur, anticorps glutamate metabotropic receptor 8, anticorps metabotropic glutamate receptor 8, anticorps glutamate receptor, metabotropic 8, anticorps GRM8, anticorps MGLUR8, anticorps LOAG_14062, anticorps Grm8
- Sujet
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Description: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Aliases: GLUR8, mGlu8, GPRC1H, MGLUR8
- Poids moléculaire
- 101.7kDa
- ID gène
- 2918
- HGNC
- 2918
- UniProt
- O00222
- Pathways
- cAMP Metabolic Process, Synaptic Membrane
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