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IGHM anticorps (AA 310-452)

IGHM Reactivité: Humain IHC, WB, FACS, ELISA, ICC, Neut Hôte: Souris Monoclonal 8B9D3 unconjugated
N° du produit ABIN5611170
  • Antigène Tous les produits IGHM
    IGHM (Immunoglobulin Heavy Constant mu (IGHM))
    Épitope
    • 4
    • 2
    • 2
    • 1
    • 1
    AA 310-452
    Reactivité
    • 25
    • 1
    • 1
    Humain
    Hôte
    • 13
    • 12
    Souris
    Clonalité
    • 16
    • 9
    Monoclonal
    Conjugué
    • 21
    • 1
    • 1
    • 1
    • 1
    Cet anticorp IGHM est non-conjugé
    Application
    • 12
    • 11
    • 10
    • 7
    • 7
    • 7
    • 6
    • 4
    • 2
    • 1
    Immunohistochemistry (IHC), Western Blotting (WB), Flow Cytometry (FACS), ELISA, Immunocytochemistry (ICC), Neutralization (Neut)
    Purification
    purified
    Immunogène
    Purified recombinant fragment of human IGHM (AA: 310-452) expressed in E. coli.
    Clone
    8B9D3
    Isotype
    IgG1
  • Indications d'application
    ELISA: 1:10000, WB: 1:200 - 1:500, ICC: N/A, FCM: 1:200 - 1:400, IHC: 1:200 - 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified antibody in PBS with 0.05 % sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    4°C, -20°C for long term storage
  • Antigène
    IGHM (Immunoglobulin Heavy Constant mu (IGHM))
    Autre désignation
    IGHM (IGHM Produits)
    Synonymes
    anticorps AI326478, anticorps Igh-6, anticorps Igh-M, anticorps Igh6, anticorps Igm, anticorps muH, anticorps ighm1, anticorps wu:fj14a08, anticorps zgc:101769, anticorps AGM1, anticorps MU, anticorps VH, anticorps immunoglobulin heavy constant mu, anticorps Ighm, anticorps ighm, anticorps IGHM
    Sujet

    Description: Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule is made up of 2 identical heavy chains and 2 identical light chains (see MIM 147200) joined by disulfide bonds so that each heavy chain is linked to a light chain and the 2 heavy chains are linked together. Each Ig heavy chain has an N-terminal variable (V) region containing the antigen-binding site and a C-terminal constant (C) region, encoded by an individual C region gene, that determines the isotype of the antibody and provides effector or signaling functions. The heavy chain V region is encoded by 1 each of 3 types of genes: V genes (see MIM 147070), joining (J) genes (see MIM 147010), and diversity (D) genes (see MIM 146910). The C region genes are clustered downstream of the V region genes within the heavy chain locus on chromosome 14. The IGHM gene encodes the C region of the mu heavy chain, which defines the IgM isotype. Naive B cells express the transmembrane forms of IgM and IgD (see IGHD, MIM 1471770) on their surface. During an antibody response, activated B cells can switch to the expression of individual downstream heavy chain C region genes by a process of somatic recombination known as isotype switching. In addition, secreted Ig forms that act as antibodies can be produced by alternative RNA processing of the heavy chain C region sequences. Although the membrane forms of all Ig isotypes are monomeric, secreted IgM forms pentamers, and occasionally hexamers, in plasma (summary by Janeway et al., 2005).

    Aliases: MU, VH, AGM1

    Poids moléculaire
    49.3 kDa
    ID gène
    3507
    HGNC
    3507
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