APC2 anticorps (AA 2041-2181)
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- Antigène Voir toutes APC2 Anticorps
- APC2 (APC Regulator of WNT Signaling Pathway 2 (APC2))
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Épitope
- AA 2041-2181
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp APC2 est non-conjugé
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Application
- ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS)
- Fonction
- APC2 Antibody
- Purification
- Purified antibody
- Immunogène
- Purified recombinant fragment of human APC2 (AA: 2041-2181) expressed in E. Coli.
- Clone
- 3A2G2
- Isotype
- IgG1
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- Indications d'application
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ELISA: 1/10000
FCM: 1/200 - 1/400
ICC: 1/200 - 1/1000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Purified antibody in PBS with 0.05 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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- Antigène
- APC2 (APC Regulator of WNT Signaling Pathway 2 (APC2))
- Autre désignation
- APC2 (APC2 Produits)
- Synonymes
- anticorps APCL, anticorps AI852447, anticorps R75424, anticorps APC2, WNT signaling pathway regulator, anticorps adenomatosis polyposis coli 2, anticorps APC2, anticorps Apc2
- Sujet
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Description: This gene encodes a strongly conserved protein that has an N-terminal coiled-coil domain followed by an armadillo domain, five 20-amino acid repeats, and two SAMP domains. This protein promotes the assembly of a multiprotein complex that recruits and phosphorylates the Wnt effector beta-catenin and targets beta-catenin for ubiquitylation and proteasomal degradation. This protein therefore plays a role in the reduction of cytoplasmic levels of beta-catenin which in turn reduces activation of Wnt target genes that play a pivotal role in the pathogenesis of various human cancers. The protein encoded by this gene is closely related to the adenomatous polyposis coli (APC) tumor-suppressor protein and has similar tumor-suppressor effects. This gene also plays a role in actin assembly, cell-cell adhesion, and microtubule network formation through its interaction with cytoskeletal proteins. This gene has its highest expression in the central nervous system and is involved in brain development through cytoskeletal regulation in neurons. Alternative splicing produces multiple transcript variants encoding distinct isoforms.
Aliases: APCL
- Poids moléculaire
- 244kDa
- ID gène
- 10297
- HGNC
- 10297
- UniProt
- O95996
- Pathways
- Signalisation WNT
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