SLAMF7 anticorps (AA 23-226)

N° du produit ABIN5611285

Détail du produit anti-SLAMF7 anticorps

Antigène: SLAMF7 (SLAM Family Member 7 (SLAMF7))

Épitope: AA 23-226

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SLAMF7 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC), Neutralization (Neut)

Purification: purified

Immunogène: Purified recombinant fragment of human CD319 (AA: extra 23-226) expressed in E. coli.

Clone: 5G5A4

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1:10000, WB: 1:500 - 1:2000, ICC: N/A, FCM: 1:200 - 1:400, IHC: 1:200 - 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: 4°C, -20°C for long term storage

Détails sur SLAMF7

Antigène: SLAMF7 (SLAM Family Member 7 (SLAMF7))

Autre désignation: CD319 (SLAMF7 Produits)

Synonymes: anticorps RGD1560190, anticorps SLAMF7, anticorps slaf7, anticorps 19A, anticorps CD319, anticorps CRACC, anticorps CS1, anticorps 19A24, anticorps 4930560D03Rik, anticorps SLAM family member 7, anticorps Slamf7, anticorps SLAMF7, anticorps slaf7

Sujet:

Description: "Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion (PubMed:11802771). In LPS-activated monocytes negatively regulates production of proinflammatory cytokines (PubMed:23695528).Isoform 3 does not mediate any NK cell activation."

Aliases: SLAMF7, 19A, CS1, CRACC

Poids moléculaire: 37.4 kDa

ID gène: 57823

HGNC: 57823