ELANE anticorps (AA 140-267)

N° du produit ABIN5611333

Détail du produit anti-ELANE anticorps

Antigène: ELANE (Elastase, Neutrophil Expressed (ELANE))

Épitope: AA 140-267

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ELANE est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)

Fonction: ELANE Antibody

Purification: Purified antibody

Immunogène: Purified recombinant fragment of human ELANE (AA: 140-267) expressed in E. Coli.

Clone: 6B6B10

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Détails sur ELANE

Antigène: ELANE (Elastase, Neutrophil Expressed (ELANE))

Autre désignation: ELANE (ELANE Produits)

Synonymes: anticorps ELA2, anticorps GE, anticorps HLE, anticorps HNE, anticorps NE, anticorps PMN-E, anticorps SCN1, anticorps Ela2, anticorps F430011M15Rik, anticorps ela2, anticorps ELANE, anticorps elastase, neutrophil expressed, anticorps proteinase 3, anticorps ELANE, anticorps Elane, anticorps prtn3

Sujet:

Description: Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to generate the active protease. Following activation, this protease hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix. The enzyme may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin. This protein also degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is present in a gene cluster on chromosome 19.

Aliases: GE, NE, HLE, HNE, ELA2, SCN1, PMN-E

Poids moléculaire: 28.5kDa

ID gène: 1991

HGNC: 1991

UniProt: P08246