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PD-1 anticorps

Name: PD-1 anticorps
Brand: antibodies-online
SKU: ABIN5633263
Price: 300.56 EUR
Availability: InStock

PDCD1 Reactivité: Humain, Non-Human Primate FACS, IHC (fro), Func Hôte: Souris Monoclonal EH12-2H7 unconjugated

Flow cytometry surface staining pattern of human peripheral blood stained using anti-human CD279 (EH12. (PD-1 anticorps)

FACS

Separation of human CD279 positive lymphocytes (red-filled) from neutrophil granulocytes (black-dashed) in flow cytometry analysis (surface staining) of human peripheral whole blood stained using anti-human CD279 (EH12. (PD-1 anticorps)

FACS

2 images

N° du produit ABIN5633263

Fiche de données

Antigène Voir toutes PD-1 (PDCD1) Anticorps

PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))
Reactivité
156

89

25

4

3

1
Humain, Non-Human Primate
Hôte
82

76

36

13

12

3

1

1
Souris
Anticorps secondaires appropriés
Clonalité
159

62

2
Monoclonal
Conjugué
99

18

14

14

9

7

5

4

4

3

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
Cet anticorp PD-1 est non-conjugé
Application
142

61

45

42

37

19

13

13

13

10

9

9

9

8

6

5

4

4

3

3

3

2

2

2

1

1

1

1

1

1
Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func)

Specificité

The mouse monoclonal antibody EH12.2H7 recognizes an extracellular epitope of CD279 / PD-1 (programmed cell death 1), a 55 kDa type I transmembrane protein expressed above all during T cell development, on activated T cells, activated B cells, and activated monocytes.

Réactivité croisée (Details)

Human, Non-Human Primates

Purification

Purified by protein-A affinity chromatography.

Pureté

> 95 % (by SDS-PAGE)

niveau d'endotoxine

Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test.

Immunogène

recombinant human CD279

Clone

EH12-2H7

Isotype

IgG1 kappa

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anti-Programmed Cell Death 1 (PDCD1) antibody
PDCD1 Reactivité: Humain, Non-Human Primate FACS, IHC (fro) Hôte: Souris Monoclonal EH12-2H7 unconjugated

Indications d'application

Functional application: Blocking.
Flow cytometry: Recommended dilution: 1-4 μg/mL

Restrictions

For Research Use only
Concentration

1 mg/mL

Buffer

Phosphate buffered saline (PBS), pH 7.4

Agent conservateur

Azide free

Stock

4 °C

Stockage commentaire

Store at 2-8°C. Do not freeze.
Antigène

PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

Autre désignation

CD279 / PD-1 (PDCD1 Produits)

Synonymes

anticorps CD279, anticorps PD-1, anticorps PD1, anticorps SLEB2, anticorps hPD-1, anticorps hPD-l, anticorps Ly101, anticorps Pdc1, anticorps programmed cell death 1, anticorps PDCD1, anticorps Pdcd1

Sujet

Programmed cell death 1,CD279 / PD-1 (programmed cell death 1), a transmembrane protein of CD28/CTLA-4 family. It is expressed inducibly mainly on activated T, B, and myeloid cells and plays a role in maintaining peripheral self-tolerance. Binding to its ligands CD273 and CD274 is associated with inhibition of T cell proliferation and induction of their anergy. It is also expressed during thymic development. Some variants of CD279 are associated with susceptibility to systemic lupus erythematosus, type 1 diabetes, and rheumatoid arthritis.,PDCD1, PD1, SLEB2

ID gène

5133

UniProt

Q15116

Pathways

Cancer Immune Checkpoints