IGF2R anticorps (Biotin)
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- Antigène Voir toutes IGF2R Anticorps
- IGF2R (Insulin-Like Growth Factor 2 Receptor (IGF2R))
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Reactivité
- Humain, Non-Human Primate
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp IGF2R est conjugé à/à la Biotin
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Application
- Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP)
- Specificité
- The antibody MEM-238 recognizes an extracellular epitope between amino acids 192-697 of CD222 (IGF2 receptor), a ubiquitously expressed 250 kDa multifunctional type I transmembrane protein. The majority of CD222 is found in the late endosomal/prelysosomal compartment, 5-10 % in the plasma membrane and the truncated (220 kDa) form of CD222 is present in human and bovine serum.
- Réactivité croisée (Details)
- Human, Non-Human Primates
- Purification
- Purified antibody is conjugated with biotin LC-NHS ester under optimum conditions and unconjugated antibody and free biotin are removed by size-exclusion chromatography.
- Immunogène
- Recombinant Vaccinia virus encoding CD222.
- Clone
- MEM-238
- Isotype
- IgG1
- Top Product
- Discover our top product IGF2R Anticorps primaire
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- Indications d'application
- Flow cytometry: Extracellular and intracellular staining, recommended dilution: 2-6 μg/mL.
- Commentaires
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The purified antibody is conjugated with Biotin-LC-NHS under optimum conditions. The reagent is free of unconjugated biotin.
- Restrictions
- For Research Use only
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- Concentration
- 1 mg/mL
- Buffer
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C
- Stockage commentaire
- Store at 2-8°C. Do not freeze.
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- Antigène
- IGF2R (Insulin-Like Growth Factor 2 Receptor (IGF2R))
- Autre désignation
- CD222 (IGF2R Produits)
- Synonymes
- anticorps CD222, anticorps CIMPR, anticorps M6P-R, anticorps MPR1, anticorps MPRI, anticorps AI661837, anticorps CI-MPR, anticorps M6P/IGF2R, anticorps Mpr300, anticorps mpri, anticorps cd222, anticorps cimpr, anticorps m6p-r, anticorps insulin like growth factor 2 receptor, anticorps insulin-like growth factor 2 receptor, anticorps IGF2R, anticorps Igf2r, anticorps igf2r
- Sujet
- Insulin like growth factor 2 receptorprovided,CD222 (CIMPR, cation-independent mannose 6-phosphate receptor, IGF2 receptor) is a ubiquitously expressed 250 kDa transmembrane protein. No more than 10 % of CD222 is present on the cell surface where it serves as a multifunctional receptor. Intracellular (major) fraction of CD222 is involved in transport of newly synthesized lysosomal enzymes modified by mannose 6-phosphate from Golgi apparatus to lysosomes. The cell surface CD222 binds and internalizes exogeneous mannose 6-phosphate-containing ligands. Importantly, CD222 is crutial for internalization and degradation of insulin-like growth factor 2, thus controling cell growth. CD222 also complexes CD87 (urokinase-type plasminogen-activator receptor), plasminogen and latent TGF-beta, last but not least CD222 serves as a receptor for heparanase and even for Listeria.,IGF2R, MPR1, CIMPR, MPR300, M6P-R
- ID gène
- 3482
- UniProt
- P11717
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