ADC anticorps

N° du produit ABIN5647667

Détail du produit anti-ADC anticorps

Antigène: ADC (Arginine Decarboxylase (ADC))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ADC est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Antigen affinity purified

Immunogène: Amino acids C111-Q301 from the human protein were used as the immunogen for the AZIN2 antibody.

Isotype: IgG

Information d'application

Indications d'application: Western blot: 0.5-1 μg/mL,IHC (FFPE): 1-2 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the AZIN2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur ADC

Antigène: ADC (Arginine Decarboxylase (ADC))

Autre désignation: AZIN2 / Antizyme inhibitor 2 (ADC Produits)

Synonymes: anticorps MGC134604, anticorps azi2, anticorps odc2, anticorps odc-p, anticorps odc1l, anticorps xodc2, anticorps ADC, anticorps AZI2, anticorps ODC-p, anticorps ODC1L, anticorps 4933429I20Rik, anticorps AZIN2, anticorps Azi2, anticorps B930082O19, anticorps Odcp, anticorps RGD1564776, anticorps odc1-b, anticorps arginine decarboxylase, anticorps antizyme inhibitor 2, anticorps biosynthetic arginine decarboxylase SpeA, anticorps biosynthetic arginine decarboxylase SpeA (ADC), anticorps pyruvoyl-dependent arginine decarboxylase, anticorps antizyme inhibitor 2 S homeolog, anticorps AZIN2, anticorps azin2, anticorps adc, anticorps speA, anticorps Mrub_2839, anticorps MMAH_RS09440, anticorps Arnit_1968, anticorps Mesil_3114, anticorps Trad_0080, anticorps Spirs_3255, anticorps LOC100233080, anticorps Azin2, anticorps azin2.S

Sujet: Antizyme inhibitor 2 (AzI2), also known as arginine decarboxylase (ADC), is an enzyme that in humans is encoded by the AZIN2 gene. The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine, however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 2, the second member of this gene family. Like AZIN1, AZIN2 interacts with all three antizymes and stimulates ODC activity and polyamine uptake. However, unlike AZIN1, which is ubiquitously expressed and localized in the nucleus and cytoplasm, AZIN2 is predominantly expressed in the brain and testis and localized in the endoplasmic reticulum-golgi intermediate compartment. Recent studies indicate that AZIN2 is also expressed in specific cell types in ovaries, adrenal glands and pancreas, and in mast cells. The exact function of this gene is not known, however, available data suggest its role in cell growth, spermiogenesis, vesicular trafficking and secretion.

UniProt: Q96A70