GRIA2 anticorps (AA 25-230)

N° du produit ABIN5663577

Détail du produit anti-GRIA2 anticorps

Antigène: GRIA2 (Glutamate Receptor, Ionotropic, AMPA 2 (GRIA2))

Épitope: AA 25-230

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GRIA2 est non-conjugé

Application: Western Blotting (WB)

Séquence: NSIQIGGLFP RGADQEYSAF RVGMVQFSTS EFRLTPHIDN LEVANSFAVT NAFCSQFSRG VYAIFGFYDK KSVNTITSFC GTLHVSFITP SFPTDGTHPF VIQMRPDLKG ALLSLIEYYQ WDKFAYLYDS DRGLSTLQAV LDSAAEKKWQ VTAINVGNIN NDKKDEMYRS LFQDLELKKE RRVILDCERD KVNDIVDQVI TIGKHV

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 25-230 of human GluR2/GluR2/GRIA2 (NP_001077088.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Références pour anticorps anti-GRIA2 (ABIN5663577)

Liu, Feng, Chen, Luo, Yan, Chen, Lin, Ding, Wen: "Dcf1 Triggers Dendritic Spine Formation and Facilitates Memory Acquisition." dans: Molecular neurobiology, Vol. 55, Issue 1, pp. 763-775, (2018) (PubMed).

Détails sur GRIA2

Antigène: GRIA2 (Glutamate Receptor, Ionotropic, AMPA 2 (GRIA2))

Autre désignation: GRIA2 (GRIA2 Produits)

Synonymes: anticorps GLUR2, anticorps GLURB, anticorps GluA2, anticorps GluR-K2, anticorps HBGR2, anticorps GluR-2, anticorps GluR-B, anticorps Glur-2, anticorps Glur2, anticorps GluR2, anticorps gluR-B, anticorps glur2a, anticorps gria2.1, anticorps zfGRIA2[a], anticorps glur2, anticorps glutamate ionotropic receptor AMPA type subunit 2, anticorps glutamate receptor, ionotropic, AMPA 2, anticorps glutamate receptor, ionotropic, AMPA2 (alpha 2), anticorps glutamate receptor, ionotropic, AMPA 2a, anticorps glutamate receptor, ionotropic, AMPA 2 S homeolog, anticorps GRIA2, anticorps Gria2, anticorps gria2a, anticorps gria2.S

Sujet: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG, Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene.,GRIA2,GLUR2,GLURB,GluA2,GluR-K2,HBGR2,Neuroscience,Neurodegenerative Diseases,Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease,Dopamine Signaling in Parkinson's Disease,GRIA2

Poids moléculaire: 93 kDa/98 kDa/100 kDa

ID gène: 2891

UniProt: P42262

Pathways: Signalisation PI3K-Akt