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Recombinant CD40L (Ruplizumab Biosimilar) anticorps

Reactivité: Humain FACS, WB, BR Hôte: Lapin Monoclonal hu5c8 unconjugated Recombinant Antibody
N° du produit ABIN5668047
  • Antigène Tous les produits CD40L (Ruplizumab Biosimilar)
    CD40L (Ruplizumab Biosimilar)
    Type d'anticorp
    Recombinant Antibody
    Reactivité
    • 3
    • 1
    Humain
    Hôte
    • 2
    • 1
    Lapin
    Clonalité
    • 3
    Monoclonal
    Conjugué
    • 3
    Cet anticorp CD40L (Ruplizumab Biosimilar) est non-conjugé
    Application
    • 3
    • 2
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Western Blotting (WB), Blocking Reagent (BR)
    Specificité
    The antibody binds to CD40L with an IC50 of 0.845 μg/mL.
    Attributs du produit

    OriginalSpeciesName: Human

    OriginalFormat: IgG1

    Purification
    Purified antibody.
    Pureté
    > 98 % as determined by SDS-PAGE
    niveau d'endotoxine
    Endotoxin is < 1.0 EU/mg as determined by the LAL method
    Immunogène
    Human CD40L
    Clone
    Hu5c8
    Isotype
    IgG kappa
  • Indications d'application
    The antibody binds specifically to CD40L, a surface receptor expressed on activated T cells which acts as a costimulatory molecule to trigger immune responses. The antibody neutralises CD40L function, as it blocks the interaction between CD40 and CD40L. When injected into cynomolgus monkeys, the original therapeutic antibody was found to have a T1/2 of 531? ±?155 hours.
    Commentaires

    NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar. This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.

    Restrictions
    For Research Use only
  • Buffer
    PBS with 0.02 % Proclin 300.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
  • Antigène
    CD40L (Ruplizumab Biosimilar)
    Abstract
    CD40L (Ruplizumab Biosimilar) Produits
    Synonymes
    anticorps CD154, anticorps CD40L, anticorps HIGM1, anticorps IGM, anticorps IMD3, anticorps T-BAM, anticorps TNFSF5, anticorps TRAP, anticorps gp39, anticorps hCD40L, anticorps CD40 ligand, anticorps CD40LG
    Classe de substances
    Biosimilar
    Sujet
    CD154, CD40 ligand, tumour necrosis factor ligand superfamily member 5, TNFSF5, tumour necrosis factor related activation protein, TRAP
    UniProt
    P29965
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