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Recombinant EGFR (Matuzumab Biosimilar) anticorps (Extracellular Domain)

Reactivité: Humain BR, FACS, WB Hôte: Lapin Chimeric unconjugated Recombinant Antibody
N° du produit ABIN5668061
  • Antigène Tous les produits EGFR (Matuzumab Biosimilar)
    EGFR (Matuzumab Biosimilar)
    Type d'anticorp
    Recombinant Antibody
    Épitope
    Extracellular Domain
    Reactivité
    Humain
    Hôte
    • 1
    • 1
    • 1
    Lapin
    Clonalité
    • 2
    • 1
    Chimeric
    Conjugué
    • 3
    Cet anticorp EGFR (Matuzumab Biosimilar) est non-conjugé
    Application
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Blocking Reagent (BR), Flow Cytometry (FACS), Western Blotting (WB)
    Specificité
    Binds to human EGFR.
    Attributs du produit

    OriginalSpeciesName: Human

    OriginalFormat: IgG1

    Purification
    Purified antibody.
    Pureté
    > 98 % as determined by SDS-PAGE
    niveau d'endotoxine
    Endotoxin is < 1.0 EU/mg as determined by the LAL method
    Immunogène
    The parental mouse antibody was generated by immunizing BALB/c mice intraperitoneally with A431 cells in phosphate buffered saline (PBS). Later on the humanzied version of the antibody was created by grafting CDRs of the murine antibody onto human constant regions.
    Isotype
    IgG kappa
  • Indications d'application
    This antibody binds to human EGFR at a side distinct frm the antigen binding site, preventing conformational re-arrangement required for dimerization, a process essential for high-affinitiy ligand binding (Schmiedel 2008).
    Commentaires

    This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.

    Restrictions
    For Research Use only
  • Buffer
    PBS with 0.02 % Proclin 300.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
  • Antigène
    EGFR (Matuzumab Biosimilar)
    Abstract
    EGFR (Matuzumab Biosimilar) Produits
    Sujet
    ErbB-1, ERBB1, HER1, EGF, Epidermal growth factor receptor, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1, EMD72000, mAb425, 425, mAb 425
    UniProt
    P00533
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