Recombinant EGFR (Matuzumab Biosimilar) anticorps (Extracellular Domain)

N° du produit ABIN5668061

Détail du produit anti-EGFR (Matuzumab Biosimilar) anticorps

Antigène: EGFR (Matuzumab Biosimilar)

Type d'anticorp: Recombinant Antibody

Épitope: Extracellular Domain

Reactivité: Humain

Hôte: Lapin

Clonalité: Chimeric

Conjugué: Cet anticorp EGFR (Matuzumab Biosimilar) est non-conjugé

Application: Blocking Reagent (BR), Flow Cytometry (FACS), Western Blotting (WB)

Specificité: Binds to human EGFR.

Attributs du produit:

OriginalSpeciesName: Human

OriginalFormat: IgG1

Purification: Purified antibody.

Pureté: > 98 % as determined by SDS-PAGE

niveau d'endotoxine: Endotoxin is < 1.0 EU/mg as determined by the LAL method

Immunogène: The parental mouse antibody was generated by immunizing BALB/c mice intraperitoneally with A431 cells in phosphate buffered saline (PBS). Later on the humanzied version of the antibody was created by grafting CDRs of the murine antibody onto human constant regions.

Isotype: IgG kappa

Information d'application

Indications d'application: This antibody binds to human EGFR at a side distinct frm the antigen binding site, preventing conformational re-arrangement required for dimerization, a process essential for high-affinitiy ligand binding (Schmiedel 2008).

Commentaires:

This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % Proclin 300.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Détails sur EGFR (Matuzumab Biosimilar)

Antigène: EGFR (Matuzumab Biosimilar)

Abstract: EGFR (Matuzumab Biosimilar) Produits

Sujet: ErbB-1, ERBB1, HER1, EGF, Epidermal growth factor receptor, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1, EMD72000, mAb425, 425, mAb 425

UniProt: P00533