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Recombinant TNF alpha (Adalimumab Biosimilar) anticorps

Reactivité: Humain ELISA, BR, IF, IHC Hôte: Human Monoclonal D2E7 unconjugated Recombinant Antibody
N° du produit ABIN5668145
  • Antigène Tous les produits TNF alpha (Adalimumab Biosimilar)
    TNF alpha (Adalimumab Biosimilar)
    Type d'anticorp
    Recombinant Antibody
    Reactivité
    Humain
    Hôte
    • 1
    • 1
    • 1
    • 1
    Human
    Clonalité
    • 4
    Monoclonal
    Conjugué
    • 4
    Cet anticorp TNF alpha (Adalimumab Biosimilar) est non-conjugé
    Application
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    ELISA, Blocking Reagent (BR), Immunofluorescence (IF), Immunohistochemistry (IHC)
    Specificité
    Binds to soluble TNF-alpha, but not to lymphotoxin (TNF beta).
    Attributs du produit

    OriginalSpeciesName: Human

    OriginalFormat: IgG1

    Purification
    Purified antibody.
    Pureté
    > 98 % as determined by SDS-PAGE
    niveau d'endotoxine
    Endotoxin is < 1.0 EU/mg as determined by the LAL method
    Immunogène
    This antibody was generated by affinity maturation from the 2SD4 scFv, which in turn was selected on human TNF alpha by guided phage-display technology, using the murine anti-hTNF alpha antibody Mab32 as a template (c.f. also US Patent 6090382).
    Clone
    D2E7
    Isotype
    IgG1 kappa
  • Indications d'application
    Adalimumab binds specifically to TNF and neutralizes the biological function of TNF by blocking its interaction with the p55 and p75 cell surface TNF receptors.
    Commentaires

    NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar.

    Restrictions
    For Research Use only
  • Buffer
    PBS with 0.02 % Proclin 300.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
  • Gupta, Flaskamp, Roentgen, Juergens, Armero-Gimenez, Albrecht, Hemmerich, Arfi, Neuser, Spiegel, Schillberg, Yeliseev, Song, Qiu, Williams, Finnern: "Scaling eukaryotic cell-free protein synthesis achieved with the versatile and high-yielding tobacco BY-2 cell lysate." dans: Biotechnology and bioengineering, (2023) (PubMed).

  • Antigène
    TNF alpha (Adalimumab Biosimilar)
    Abstract
    TNF alpha (Adalimumab Biosimilar) Produits
    Synonymes
    anticorps DIF, anticorps TNF-alpha, anticorps TNFA, anticorps TNFSF2, anticorps tumor necrosis factor, anticorps TNF
    Classe de substances
    Biosimilar
    Sujet
    Tumor necrosis factor alpha
    UniProt
    P01375
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