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Recombinant RSV (Felvizumab Biosimilar) anticorps

Reactivité: Respiratory Syncytial Virus (RSV) ELISA, Func Hôte: Lapin Monoclonal RSHZ19 unconjugated Recombinant Antibody
N° du produit ABIN5668207
  • Antigène Tous les produits RSV (Felvizumab Biosimilar)
    RSV (Felvizumab Biosimilar)
    Type d'anticorp
    Recombinant Antibody
    Reactivité
    Respiratory Syncytial Virus (RSV)
    Hôte
    • 1
    Lapin
    Clonalité
    • 1
    Monoclonal
    Conjugué
    • 1
    Cet anticorp RSV (Felvizumab Biosimilar) est non-conjugé
    Application
    ELISA, Functional Studies (Func)
    Specificité
    This antibody is specific for the conserved fusion (F) protein of RSV.
    Attributs du produit

    OriginalSpeciesName: Human

    OriginalFormat: IgG1

    Purification
    Purified antibody.
    Pureté
    > 98 % as determined by SDS-PAGE
    niveau d'endotoxine
    Endotoxin is < 1.0 EU/mg as determined by the LAL method
    Immunogène
    This antibody was prepared by the humanization of an F protein-specific murine MAb, RSV19. More specifically, molecular techniques were used to insert the complementarity determining regions from murine RSV19 into a human IgG1 heavy and k light chain-variable domain framework.
    Clone
    RSHZ19
    Isotype
    IgG kappa
  • Indications d'application
    Though shown to be safe and well-tolerated (Everitt, 1996) and protective against RSV infection in BALB/c mice and cotton rats (Wyde, 1995), this antibody did not demonstrate efficacy in a Phase 3 study (Reichert, 2008). In in vitro studies, palivizumab, another humanized Mab specific for the F protein of RSV, was 4 to 5-fold more potent than felvizumab in neutralising RSV (Scott, 1999).
    Commentaires

    This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.

    Restrictions
    For Research Use only
  • Buffer
    PBS with 0.02 % Proclin 300.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
  • Antigène
    RSV (Felvizumab Biosimilar)
    Abstract
    RSV (Felvizumab Biosimilar) Produits
    Classe de substances
    Biosimilar
    Sujet
    SB 209763, respiratory syncytial virus
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