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Recombinant ErbB2/Her2 (Trastuzumab Biosimilar) anticorps

Reactivité: Humain FACS, ELISA, IHC Hôte: Human Monoclonal 4D5-8 unconjugated Recombinant Antibody
N° du produit ABIN5668226
  • Antigène Tous les produits ErbB2/Her2 (Trastuzumab Biosimilar)
    ErbB2/Her2 (Trastuzumab Biosimilar)
    Type d'anticorp
    Recombinant Antibody
    Reactivité
    Humain
    Hôte
    • 1
    • 1
    • 1
    • 1
    Human
    Clonalité
    • 4
    Monoclonal
    Conjugué
    • 4
    Cet anticorp ErbB2/Her2 (Trastuzumab Biosimilar) est non-conjugé
    Application
    • 3
    • 2
    • 1
    • 1
    Flow Cytometry (FACS), ELISA, Immunohistochemistry (IHC)
    Specificité
    Oncogenic protein Her-2/neu (erbB-2), a member of the family of epidermal growth factor (EGF) receptors, overexpressed in 30 % of invasive breast cancers and 70 % of ductal carcinomata in situ, in a small percentage of melanomas, and in other malignancies originating from various organs, including ovary, kidney, colon, and bladder.
    Attributs du produit

    OriginalSpeciesName: Human

    OriginalFormat: IgG1

    Purification
    Purified antibody.
    Pureté
    > 98 % as determined by SDS-PAGE
    niveau d'endotoxine
    Endotoxin is < 1.0 EU/mg as determined by the LAL method
    Immunogène
    A431 cells (human epidermoid carcinoma) (over)expressing EGFR.
    Clone
    4D5-8
    Isotype
    IgG1 kappa
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Commentaires

    NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar.

    Restrictions
    For Research Use only
  • Buffer
    PBS with 0.02 % Proclin 300.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
  • Maisel, Broka, Atwell, Bunch, Kupp, Singh, Mehta, Schroeder: "Stapled EGFR peptide reduces inflammatory breast cancer and inhibits additional HER-driven models of cancer." dans: Journal of translational medicine, Vol. 17, Issue 1, pp. 201, (2020) (PubMed).

  • Antigène
    ErbB2/Her2 (Trastuzumab Biosimilar)
    Abstract
    ErbB2/Her2 (Trastuzumab Biosimilar) Produits
    Synonymes
    anticorps CD340, anticorps HER-2, anticorps HER-2/neu, anticorps HER2, anticorps MLN 19, anticorps NEU, anticorps NGL, anticorps TKR1, anticorps erb-b2 receptor tyrosine kinase 2, anticorps ERBB2
    Classe de substances
    Biosimilar
    Sujet
    CD340, Metastatic lymph node gene 19 protein (MLN 19), Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Tyrosine kinase-type cell surface receptor HER2, p185erbB2, p185HER2, EGFR
    UniProt
    P04626
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