Recombinant IL-6R (Tocilizumab Biosimilar) anticorps

N° du produit ABIN5668253

Détail du produit anti-IL-6R (Tocilizumab Biosimilar) anticorps

Antigène: IL-6R (Tocilizumab Biosimilar)

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Human

Clonalité: Monoclonal

Conjugué: Cet anticorp IL-6R (Tocilizumab Biosimilar) est non-conjugé

Application: ELISA, Inhibition Assay (InhA)

Specificité: Tocilizumab binds specifically to both the membrane bound and soluble forms of human IL-6R. The IL6 receptor is a protein complex consisting of an IL-6 receptor subunit (IL6R) and interleukin 6 signal transducer Glycoprotein 130. Interleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response.

Attributs du produit:

OriginalSpeciesName: Human

OriginalFormat: IgG1

Purification: Purified antibody.

Pureté: > 98 % as determined by SDS-PAGE

niveau d'endotoxine: Endotoxin is < 1.0 EU/mg as determined by the LAL method

Immunogène: This antibody was prepared by CDR grafting of mouse AUK 12-20 antibody onto a human framework regions.

Clone: RhPM-1

Isotype: IgG1 kappa

Information d'application

Indications d'application: Tocilizumab can be used in ELISA assays and is able to inhibit the growth of IL-6-dependent tumor cell lines (to the same extent as the original AUK12-20 mouse antibody) - inhibits sIL-6R and mIL-6R-mediated signaling.

Commentaires:

NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar.

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % Proclin 300.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Références pour anticorps anti-IL-6R (Tocilizumab Biosimilar) (ABIN5668253)

Hsieh, Hsu, Chang, Lai: "IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells." dans: Nature communications, Vol. 9, Issue 1, pp. 463, (2018) (PubMed).

Détails sur IL-6R (Tocilizumab Biosimilar)

Antigène: IL-6R (Tocilizumab Biosimilar)

Abstract: IL-6R (Tocilizumab Biosimilar) Produits

Synonymes: anticorps CD126, anticorps IL-6R-1, anticorps IL-6RA, anticorps IL6Q, anticorps IL6RA, anticorps IL6RQ, anticorps gp80, anticorps interleukin 6 receptor, anticorps IL6R

Classe de substances: Biosimilar

Sujet: IL6R, MRA, atlizumab

UniProt: A0N0L5