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Recombinant IL-6R (Tocilizumab Biosimilar) anticorps

Reactivité: Humain ELISA, InhA Hôte: Human Monoclonal RhPM-1 unconjugated Recombinant Antibody
N° du produit ABIN5668253
  • Antigène Tous les produits IL-6R (Tocilizumab Biosimilar)
    IL-6R (Tocilizumab Biosimilar)
    Type d'anticorp
    Recombinant Antibody
    Reactivité
    Humain
    Hôte
    • 1
    • 1
    • 1
    Human
    Clonalité
    • 3
    Monoclonal
    Conjugué
    • 3
    Cet anticorp IL-6R (Tocilizumab Biosimilar) est non-conjugé
    Application
    • 3
    • 1
    • 1
    ELISA, Inhibition Assay (InhA)
    Specificité
    Tocilizumab binds specifically to both the membrane bound and soluble forms of human IL-6R. The IL6 receptor is a protein complex consisting of an IL-6 receptor subunit (IL6R) and interleukin 6 signal transducer Glycoprotein 130. Interleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response.
    Attributs du produit

    OriginalSpeciesName: Human

    OriginalFormat: IgG1

    Purification
    Purified antibody.
    Pureté
    > 98 % as determined by SDS-PAGE
    niveau d'endotoxine
    Endotoxin is < 1.0 EU/mg as determined by the LAL method
    Immunogène
    This antibody was prepared by CDR grafting of mouse AUK 12-20 antibody onto a human framework regions.
    Clone
    RhPM-1
    Isotype
    IgG1 kappa
  • Indications d'application
    Tocilizumab can be used in ELISA assays and is able to inhibit the growth of IL-6-dependent tumor cell lines (to the same extent as the original AUK12-20 mouse antibody) - inhibits sIL-6R and mIL-6R-mediated signaling.
    Commentaires

    NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar.

    Restrictions
    For Research Use only
  • Buffer
    PBS with 0.02 % Proclin 300.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
  • Hsieh, Hsu, Chang, Lai: "IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells." dans: Nature communications, Vol. 9, Issue 1, pp. 463, (2018) (PubMed).

  • Antigène
    IL-6R (Tocilizumab Biosimilar)
    Abstract
    IL-6R (Tocilizumab Biosimilar) Produits
    Synonymes
    anticorps CD126, anticorps IL-6R-1, anticorps IL-6RA, anticorps IL6Q, anticorps IL6RA, anticorps IL6RQ, anticorps gp80, anticorps interleukin 6 receptor, anticorps IL6R
    Classe de substances
    Biosimilar
    Sujet
    IL6R, MRA, atlizumab
    UniProt
    A0N0L5
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