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Recombinant IL-6R (Tocilizumab Biosimilar) anticorps

Reactivité: Humain ELISA, InhA Hôte: Lapin Monoclonal RhPM-1 unconjugated Recombinant Antibody
N° du produit ABIN5668254
  • Antigène Tous les produits IL-6R (Tocilizumab Biosimilar)
    IL-6R (Tocilizumab Biosimilar)
    Type d'anticorp
    Recombinant Antibody
    Reactivité
    Humain
    Hôte
    • 1
    • 1
    • 1
    Lapin
    Clonalité
    • 3
    Monoclonal
    Conjugué
    • 3
    Cet anticorp IL-6R (Tocilizumab Biosimilar) est non-conjugé
    Application
    • 3
    • 1
    • 1
    ELISA, Inhibition Assay (InhA)
    Specificité
    Tocilizumab binds specifically to both the membrane bound and soluble forms of human IL-6R. The IL6 receptor is a protein complex consisting of an IL-6 receptor subunit (IL6R) and interleukin 6 signal transducer Glycoprotein 130. Interleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response.
    Attributs du produit

    OriginalSpeciesName: Human

    OriginalFormat: IgG1

    Purification
    Purified antibody.
    Pureté
    > 98 % as determined by SDS-PAGE
    niveau d'endotoxine
    Endotoxin is < 1.0 EU/mg as determined by the LAL method
    Immunogène
    This antibody was prepared by CDR grafting of mouse AUK 12-20 antibody onto a human framework regions.
    Clone
    RhPM-1
    Isotype
    IgG kappa
  • Indications d'application
    Tocilizumab can be used in ELISA assays and is able to inhibit the growth of IL-6-dependent tumor cell lines (to the same extent as the original AUK12-20 mouse antibody) - inhibits sIL-6R and mIL-6R-mediated signaling.
    Commentaires

    This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.

    Restrictions
    For Research Use only
  • Buffer
    PBS with 0.02 % Proclin 300.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
  • Antigène
    IL-6R (Tocilizumab Biosimilar)
    Abstract
    IL-6R (Tocilizumab Biosimilar) Produits
    Synonymes
    anticorps CD126, anticorps IL-6R-1, anticorps IL-6RA, anticorps IL6Q, anticorps IL6RA, anticorps IL6RQ, anticorps gp80, anticorps interleukin 6 receptor, anticorps IL6R
    Classe de substances
    Biosimilar
    Sujet
    IL6R, MRA, atlizumab
    UniProt
    A0N0L5
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