DNMT3B anticorps (AA 251-350)

N° du produit ABIN5675299

Détail du produit anti-DNMT3B anticorps

Antigène: DNMT3B (DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B))

Épitope: AA 251-350

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DNMT3B est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS)

Réactivité croisée: Humain, Souris

Homologie: Dog,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Dnmt3b

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
FCM 1:20-100

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur DNMT3B

Antigène: DNMT3B (DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B))

Autre désignation: Dnmt3b (DNMT3B Produits)

Synonymes: anticorps DNMT3B, anticorps LOC100218113, anticorps ICF, anticorps ICF1, anticorps M.HsaIIIB, anticorps MmuIIIB, anticorps cb91, anticorps dnmt3bl, anticorps dnmt7, anticorps sb:cb91, anticorps wu:fb16h07, anticorps DNA methyltransferase 3 beta, anticorps DNA methyltransferase 3B, anticorps DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a, anticorps DNMT3B, anticorps Dnmt3b, anticorps dnmt3b, anticorps dnmt3ba

Sujet:

Synonyms: DNA (cytosine-5)-methyltransferase 3B, DNMT3B, DNA methyltransferase HsaIIIB, DNA MTase HsaIIIB, M.HsaIIIB

Background: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity). In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Function as transcriptional corepressor by associating with ZHX1. Required for DUX4 silencing in somatic cells (PubMed:27153398).

ID gène: 1789

UniProt: Q9UBC3