MERTK anticorps (pTyr749)

N° du produit ABIN5675320

Détail du produit anti-MERTK anticorps

Antigène: MERTK (C-Mer Proto-Oncogene Tyrosine Kinase (MERTK))

Épitope: pTyr749

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MERTK est non-conjugé

Application: Western Blotting (WB), ELISA

Réactivité croisée: Humain, Souris

Homologie: Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthesised phosphopeptide derived from human MERTK around the phosphorylation site of Tyr749

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur MERTK

Antigène: MERTK (C-Mer Proto-Oncogene Tyrosine Kinase (MERTK))

Autre désignation: MERTK (MERTK Produits)

Synonymes: anticorps MER, anticorps RP38, anticorps c-mer, anticorps Eyk, anticorps Mer, anticorps Nyk, anticorps nmf12, anticorps rdy, anticorps C-EYK, anticorps MERTK, anticorps DKFZp469D2215, anticorps si:ch1073-268l12.2, anticorps MER proto-oncogene, tyrosine kinase, anticorps c-mer proto-oncogene tyrosine kinase, anticorps c-mer proto-oncogene tyrosine kinase a, anticorps MERTK, anticorps Mertk, anticorps mertka

Sujet:

Synonyms: Tyrosine-protein kinase Mer, MERTK, Proto-oncogene c-Mer, Receptor tyrosine kinase MerTK, MER

Background: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

ID gène: 10461

UniProt: Q12866

Pathways: Signalisation RTK