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KPNA4 anticorps (AA 1-100)

KPNA4 Reactivité: Souris WB, ELISA, IF (p), IF (cc), IHC (p), ICC, IHC (fro) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN5675543
  • Antigène Voir toutes KPNA4 Anticorps
    KPNA4 (Karyopherin (Importin) alpha 4 (KPNA4))
    Épitope
    • 14
    • 7
    • 6
    • 6
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-100
    Reactivité
    • 41
    • 37
    • 15
    • 5
    • 4
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    Souris
    Hôte
    • 50
    • 1
    • 1
    Lapin
    Clonalité
    • 51
    • 1
    Polyclonal
    Conjugué
    • 22
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp KPNA4 est non-conjugé
    Application
    • 39
    • 19
    • 13
    • 12
    • 11
    • 9
    • 6
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))
     Réactivité croisée
    Souris
    Homologie
    Human,Rat,Cow,Horse,Chicken
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human KPNA4
    Isotype
    IgG
    Top Product
    Discover our top product KPNA4 Anticorps primaire
  • Indications d'application
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Date de péremption
    12 months
  • Antigène
    KPNA4 (Karyopherin (Importin) alpha 4 (KPNA4))
    Autre désignation
    KPNA4 (KPNA4 Produits)
    Synonymes
    anticorps IPOA3, anticorps QIP1, anticorps SRP3, anticorps 6, anticorps ATIMPALPHA3, anticorps IMPA-3, anticorps IMPORTIN ALPHA 3, anticorps IMPORTIN ALPHA ISOFORM 3, anticorps MODIFIER OF SNC1, anticorps T10M13.16, anticorps T10M13_16, anticorps LOC100224013, anticorps 1110058D08Rik, anticorps importin, anticorps ipoa3, anticorps qip1, anticorps srp3, anticorps impa3, anticorps wu:fa56d07, anticorps wu:fa66g10, anticorps wu:fe14c04, anticorps wu:fi04h11, anticorps wu:fi19b05, anticorps karyopherin subunit alpha 4, anticorps ARM repeat superfamily protein, anticorps importin alpha 3, anticorps karyopherin (importin) alpha 4, anticorps karyopherin alpha 4 (importin alpha 3) S homeolog, anticorps karyopherin alpha 4 (importin alpha 3), anticorps KPNA4, anticorps MOS6, anticorps LOC100533341, anticorps Kpna4, anticorps kpna4.S, anticorps kpna4
    Sujet

    Synonyms: Importin subunit alpha-3, KPNA4, Importin alpha Q1, Qip1, Karyopherin subunit alpha-4, QIP1

    Background: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a nonclassical NLS.

    ID gène
    3840
    UniProt
    O00629
    Pathways
    Protein targeting to Nucleus
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