FLT4 anticorps (Extracellular Domain)
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- Antigène Voir toutes FLT4 Anticorps
- FLT4 (Fms-Related Tyrosine Kinase 4 (FLT4))
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Épitope
- Extracellular Domain
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp FLT4 est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)
- Specificité
- This antibody detects Human VEGFR-3/FLT-4. Other species not tested.
- Purification
- Affinity Chromatography on Protein G.
- Immunogène
- Recombinant Human Vascular Endothelial Growth Factor Receptor 3 (rh VEGFR-3/FLT-4) extracellular domain
- Clone
- 2-00E-011
- Isotype
- IgG1
- Top Product
- Discover our top product FLT4 Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Reconstitution
- Restore in Sterile water to a concentration of 0.1-1.0 mg/mL
- Concentration
- 0.5 mg/mL
- Buffer
- PBS, pH 7.4 without preservatives
- Agent conservateur
- Without preservative
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Prior to reconstitution store at 2-8 °C for 6 month or at -20 °C for longer. Following reconstitution store the antibody undiluted at 2-8 °C for one month.
- Date de péremption
- 6 months
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- Antigène
- FLT4 (Fms-Related Tyrosine Kinase 4 (FLT4))
- Autre désignation
- VEGFR-3 / Flt-4 (FLT4 Produits)
- Synonymes
- anticorps FLT41, anticorps LMPH1A, anticorps PCL, anticorps VEGFR3, anticorps AI323512, anticorps Chy, anticorps Flt-4, anticorps VEGFR-3, anticorps Vegfr3, anticorps cb1059, anticorps fms related tyrosine kinase 4, anticorps FMS-like tyrosine kinase 4, anticorps fms-related tyrosine kinase 4, anticorps FLT4, anticorps Flt4, anticorps flt4
- Sujet
- VEGFR-1 (Flt-1), VEGFR-2 (KDR/Flk 1) and VEGFR-3 (FLT-4) belong to the class III subfamily of receptor tyrosine kinases (RTKs). All three receptors contain seven immunoglobulin-like repeats in their extracellular domains and kinase insert domains in their intracellular regions. The expression of VEGFR-1 to -3 is almost exclusively restricted to hematopoietic precursor cells, vascular and lymphatic endothelial cells and to the monocyte/macrophage lineage. These receptors play essential roles in vasculogenesis, hematopoiesis, angiogenesis and lymphangiogenesis. The VEGFR-3 cDNA encodes a 1298 amino acid (aa) residue precursor protein with a 24 aa residue signal peptide. Mature VEGFR-3 is composed of a 751 aa residue extracellular domain, a 22 aa residue transmembrane domain and a 482 aa residue cytoplasmic domain. Both VEGF-C and VEGF-D have been shown to bind and activate VEGF R3 (Flt-4). The Flt-4 gene is widely expressed in the early embryo but becomes restricted to the lymphatic endothelial a latter stage of development. It is important for lymphangiogenesis.Synonyms: FLT4, Tyrosine-protein kinase receptor FLT4, VEGF Receptor 3, VEGFR3, Vascular endothelial growth factor receptor 3
- ID gène
- 2324
- NCBI Accession
- NP_002011
- UniProt
- P35916
- Pathways
- Signalisation RTK, Signaling Events mediated by VEGFR1 and VEGFR2, VEGF Signaling
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