CD80 anticorps
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- Antigène Voir toutes CD80 Anticorps
- CD80
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Reactivité
- Souris, Chien
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Hôte
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Hamster
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp CD80 est non-conjugé
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Application
- Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func)
- Specificité
- This Hamster antibody reacts with CD80 (B7-1), a 60 kDa single chain type I glycoprotein of immunoglobulin supergene family, expressed on professional antigen-presenting cells, such as dendritic cells, macrophages or activated B lymphocytes.
- Réactivité croisée (Details)
- Species reactivity (tested):Mouse, Canine (Dog).
- Purification
- Protein-A affinity chromatography
- Immunogène
- CD80-transfected CHO cell line
- Clone
- 16-10A1
- Isotype
- IgG2
- Top Product
- Discover our top product CD80 Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- Phosphate buffered saline (PBS), pH ~7.4 with 15 mM Sodium Azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store at 2-8 °C for up to one month or (in aliquots) at -20 °C for longer.
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Modulation of cell cycle progression by CTLA4-CD80/CD86 interactions on CD4+ T cells depends on strength of the CD3 signal: critical role for IL-2." dans: Journal of leukocyte biology, Vol. 80, Issue 1, pp. 66-74, (2006) (PubMed).
: "Glomerular expression of CD80 and CD86 is required for leukocyte accumulation and injury in crescentic glomerulonephritis." dans: Journal of the American Society of Nephrology : JASN, Vol. 16, Issue 7, pp. 2012-22, (2005) (PubMed).
: "SC5 mAb represents a unique tool for the detection of extracellular vimentin as a specific marker of Sezary cells." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 176, Issue 1, pp. 652-9, (2005) (PubMed).
: "Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 28, pp. 10398-403, (2004) (PubMed).
: "Induction of B7-1 in podocytes is associated with nephrotic syndrome." dans: The Journal of clinical investigation, Vol. 113, Issue 10, pp. 1390-7, (2004) (PubMed).
: "In vitro hematopoiesis produces a distinct class of immature dendritic cells from spleen progenitors with limited T cell stimulation capacity." dans: International immunology, Vol. 16, Issue 4, pp. 567-77, (2004) (PubMed).
: "CD80+Gr-1+ myeloid cells inhibit development of antifungal Th1 immunity in mice with candidiasis." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 169, Issue 6, pp. 3180-90, (2002) (PubMed).
: "Nucleic acid vaccine-induced immune responses require CD28 costimulation and are regulated by CTLA4." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 160, Issue 6, pp. 2706-14, (1998) (PubMed).
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Modulation of cell cycle progression by CTLA4-CD80/CD86 interactions on CD4+ T cells depends on strength of the CD3 signal: critical role for IL-2." dans: Journal of leukocyte biology, Vol. 80, Issue 1, pp. 66-74, (2006) (PubMed).
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- Antigène
- CD80
- Autre désignation
- CD80 (CD80 Produits)
- Synonymes
- anticorps B7, anticorps B7-1, anticorps B7.1, anticorps BB1, anticorps CD28LG, anticorps CD28LG1, anticorps LAB7, anticorps B71, anticorps Cd28l, anticorps Ly-53, anticorps Ly53, anticorps MIC17, anticorps TSA1, anticorps CD80 molecule, anticorps Cd80 molecule, anticorps CD80 antigen, anticorps CD80, anticorps Cd80
- Sujet
- CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28 and of an inhibitory receptor CTLA-4 (CD152). The both B7 Molecules are expressed on professional antigen-presenting cells and are essential for T cell activation, the both molecules can also substitute for each other in this process. The question what are the differences in CD80 and CD86 competency has not been fully elucidated yet, there are still conflicts in results about their respective roles in initiation or sustaining of the T cell immune response.Synonyms: Activation B7-1 antigen, B7-1, B7.1, BB1, CD28LG, CD28LG1, CTLA-4 counter-receptor B7.1, LAB7, T-lymphocyte activation antigen CD80
- ID gène
- 12519
- NCBI Accession
- NP_033985
- UniProt
- Q00609
- Pathways
- TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints
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