TBC1D4 anticorps (AA 574-712)

N° du produit ABIN5684096

Détail du produit anti-TBC1D4 anticorps

Antigène: TBC1D4 (TBC1 Domain Family, Member 4 (TBC1D4))

Épitope: AA 574-712

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TBC1D4 est non-conjugé

Application: ELISA, Flow Cytometry (FACS)

Fonction: TBC1D4 Antibody

Purification: Purified antibody

Immunogène: Purified recombinant fragment of human TBC1D4 (AA: 574-712) expressed in E. Coli.

Clone: 8A11A2

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Détails sur TBC1D4

Antigène: TBC1D4 (TBC1 Domain Family, Member 4 (TBC1D4))

Autre désignation: TBC1D4 (TBC1D4 Produits)

Synonymes: anticorps AS160, anticorps 5930406J04Rik, anticorps A930035N22, anticorps AV295684, anticorps As160, anticorps RGD1561609, anticorps TBC1 domain family member 4, anticorps TBC1 domain family, member 4, anticorps TBC1D4, anticorps Tbc1d4

Sujet:

Description: This gene is a member of the Tre-2/BUB2/CDC16 domain family. The protein encoded by this gene is a Rab-GTPase-activating protein, and contains two phopshotyrosine-binding domains (PTB1 and PTB2), a calmodulin-binding domain (CBD), a Rab-GTPase domain, and multiple AKT phosphomotifs. This protein is thought to play an important role in glucose homeostasis by regulating the insulin-dependent trafficking of the glucose transporter 4 (GLUT4), important for removing glucose from the bloodstream into skeletal muscle and fat tissues. Reduced expression of this gene results in an increase in GLUT4 levels at the plasma membrane, suggesting that this protein is important in intracellular retention of GLUT4 under basal conditions. When exposed to insulin, this protein is phosphorylated, dissociates from GLUT4 vesicles, resulting in increased GLUT4 at the cell surface, and enhanced glucose transport. Phosphorylation of this protein by AKT is required for proper translocation of GLUT4 to the cell surface. Individuals homozygous for a mutation in this gene are at higher risk for type 2 diabetes and have higher levels of circulating glucose and insulin levels after glucose ingestion. Alternative splicing results in multiple transcript variants encoding different isoforms.

Aliases: AS160, NIDDM5

Poids moléculaire: 146.5kDa

ID gène: 9882

HGNC: 23495

UniProt: O60343