BNIP3 anticorps
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- Antigène Voir toutes BNIP3 Anticorps
- BNIP3 (BCL2/adenovirus E1B 19kDa Interacting Protein 3 (BNIP3))
- Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp BNIP3 est non-conjugé
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Application
- Western Blotting (WB)
- Marque
- Picoband™
- Séquence
- KEFLFKHPKR TATLSMRNTS VMKK
- Réactivité croisée (Details)
- No cross reactivity with other proteins.
- Attributs du produit
- Rabbit IgG polyclonal antibody for BNIP3 detection. Tested with WB in Human,Mouse,Rat.
- Immunogène
- A synthetic peptide corresponding to a sequence of human BNIP3 (KEFLFKHPKRTATLSMRNTSVMKK).
- Top Product
- Discover our top product BNIP3 Anticorps primaire
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- Indications d'application
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Recommended Detection Systems: Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ABIN921124) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).
Application Details: Western blot, 0.1-0.5 μg/mL
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
- Buffer
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
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At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.
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MicroRNA-145 induces apoptosis of glioma cells by targeting BNIP3 and Notch signaling." dans: Oncotarget, Vol. 8, Issue 37, pp. 61510-61527, (2017) (PubMed).
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MicroRNA-145 induces apoptosis of glioma cells by targeting BNIP3 and Notch signaling." dans: Oncotarget, Vol. 8, Issue 37, pp. 61510-61527, (2017) (PubMed).
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- Antigène
- BNIP3 (BCL2/adenovirus E1B 19kDa Interacting Protein 3 (BNIP3))
- Autre désignation
- BNIP3 (BNIP3 Produits)
- Synonymes
- anticorps NIP3, anticorps Nip3, anticorps BCL2 interacting protein 3, anticorps BCL2/adenovirus E1B interacting protein 3, anticorps BNIP3, anticorps Bnip3
- Sujet
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Synonyms: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3, BNIP3, NIP3
Background: The Bcl-2 nineteen kilodalton interacting protein 3 (BNIP3 or NIP3), is a hypoxia-inducible proapoptotic member of the Bcl-2 family that induces cell death by associating with the mitochondria. BNIP3, expressed in skeletal muscle and in the brain at low levels, is primarily localized to the nucleus of glial cells of the normal human brain, as well as in the malignant glioma cell line U251. BNIP3 expression in the cytoplasm increases and localizes with the mitochondria, contributing to induction of cell death. Cellular protein BNIP3 interacts with E1B-19K, BCL-2, BCL-xL, and EBV-BHRF1. BNIP3 contains Bcl-2 homology 3 (BH3) domain and COOH-terminal transmembrane (TM) domain. The BH3 domain of BNIP3 mediates Bcl-2/Bcl-X(L) heterodimerization and confers pro-apoptotic activity, whereas the TM domain is critical for homodimerization, pro-apoptotic function, and mitochondrial targeting.
- UniProt
- Q12983
- Pathways
- Autophagy, Brown Fat Cell Differentiation
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