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ESRRG anticorps (AA 302-458)

ESRRG Reactivité: Humain, Souris, Rat WB, ELISA, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN5693179
  • Antigène Voir toutes ESRRG Anticorps
    ESRRG (Estrogen-Related Receptor gamma (ESRRG))
    Épitope
    • 15
    • 7
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 302-458
    Reactivité
    • 38
    • 35
    • 27
    • 9
    • 8
    • 8
    • 8
    • 6
    • 6
    • 5
    • 5
    • 5
    • 4
    • 4
    • 3
    Humain, Souris, Rat
    Hôte
    • 48
    • 4
    • 1
    Lapin
    Clonalité
    • 50
    • 3
    Polyclonal
    Conjugué
    • 29
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp ESRRG est non-conjugé
    Application
    • 36
    • 13
    • 13
    • 12
    • 12
    • 9
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Marque
    Picoband™
    Réactivité croisée (Details)
    No cross reactivity with other proteins.
    Attributs du produit
    Rabbit IgG polyclonal antibody for ESRRG detection. Tested with WB, IHC-P, Direct ELISA in Human,Mouse,Rat.
    Immunogène
    E. coli-derived human ESRRG recombinant protein (Position: Q302-V458).
    Top Product
    Discover our top product ESRRG Anticorps primaire
  • Indications d'application

    Recommended Detection Systems: Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ABIN921124) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).

    Application Details: Western blot, 0.1-0.5 μg/mL
    Immunohistochemistry(Paraffin-embedded Section), 0.5-1 μg/mL
    Direct ELISA, 0.1-0.5 μg/mL

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Buffer
    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.
  • Antigène
    ESRRG (Estrogen-Related Receptor gamma (ESRRG))
    Autre désignation
    ESRRG (ESRRG Produits)
    Synonymes
    anticorps ERR3, anticorps ERRgamma, anticorps NR3B3, anticorps ESRRG, anticorps USH2A, anticorps DKFZp459J0417, anticorps err3, anticorps nr3b3, anticorps LOC100219115, anticorps errg, anticorps errgamma, anticorps esrrg, anticorps errb/g, anticorps esrrgl, anticorps errbeta/gamma, anticorps Errg, anticorps mKIAA0832, anticorps estrogen related receptor gamma, anticorps estrogen-related receptor gamma, anticorps estrogen-related receptor gamma a, anticorps estrogen-related receptor gamma b, anticorps ESRRG, anticorps esrrg, anticorps Esrrg, anticorps esrrga, anticorps esrrgb
    Sujet

    Synonyms: Estrogen-related receptor gamma, ERR gamma-2, Estrogen receptor-related protein 3, Nuclear receptor subfamily 3 group B member 3, ESRRG, ERR3, ERRG2, KIAA0832, NR3B3

    Tissue Specificity: Expressed in the heart, kidney, brain, lung, bone marrow, adrenal gland, trachea, spinal cord and thyroid gland.

    Background: Estrogen-related receptor gamma (ERR-gamma), also known as NR3B3, is a nuclear receptor that in humans is encoded by the ESRRG gene. This gene encodes a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors, they bind to the estrogen response element and steroidogenic factor 1 response element, and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes, co-regulators and promoters, and by targeting the same set of genes, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. Multiple alternatively spliced transcript variants have been identified, which mainly differ at the 5' end and some of which encode protein isoforms differing in the N-terminal region.

    UniProt
    P62508
    Pathways
    Nuclear Receptor Transcription Pathway, Retinoic Acid Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway
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