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SNAIL anticorps (N-Term)
SNAI1
Reactivité: Humain, Souris, Rat
WB, IHC (p), EIA
Hôte: Chèvre
Polyclonal
unconjugated
Détail du produit anti-SNAIL anticorps
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Antigène
Voir toutes SNAIL (SNAI1) Anticorps
SNAIL (SNAI1)
Épitope
Tous les épitopes à travers SNAIL Anticorps.
N-Term
Reactivité
Toutes les réactivités sur SNAIL Anticorps
Humain, Souris, Rat
Hôte
Toutes les hôtes sur SNAIL Anticorps
Chèvre
Clonalité
Toutes les clonalités sur SNAIL Anticorps
Polyclonal
Conjugué
Tous les conjugués à travers SNAIL Anticorps
Cet anticorp SNAIL est non-conjugé
Application
Tous les applications à travers SNAIL Anticorps.
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
Séquence
RKPSDPNRKP NY-C
Specificité
Snail homolog 1 / SNAI1
Réactivité croisée (Details)
Species reactivity (expected):Rat. Species reactivity (tested):Human, Mouse.
Purification
Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide
Immunogène
Peptide with sequence from the N Terminus of the protein sequence according to NP_005976.2. Genename: SNAI1
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Information d'application
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Indications d'application
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Stockage
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Concentration
0.5 mg/mL
Buffer
Tris saline, pH ~7.3 with 0.02 % Sodium Azide and 0.5 % BSA
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation
Avoid repeated freezing and thawing.
Stock
4 °C/-20 °C
Stockage commentaire
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Détails sur SNAIL
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Antigène
SNAIL (SNAI1)
Autre désignation
SNAI1 (SNAI1 Produits )
Synonymes
anticorps SLUGH2, anticorps SNA, anticorps SNAH, anticorps SNAIL, anticorps SNAIL1, anticorps dJ710H13.1, anticorps AI194338, anticorps Sna, anticorps Sna1, anticorps Snail, anticorps Snail1, anticorps SNAI1, anticorps BG:DS01845.1, anticorps CG3956, anticorps Dmel\\CG3956, anticorps Sco, anticorps br28, anticorps br29, anticorps l(2)35Db, anticorps l(2)br28, anticorps l(2)br29, anticorps l(3)br28, anticorps l35Db, anticorps sn, anticorps Xsnail, anticorps sna, anticorps snail1, anticorps xSna, anticorps Snai, anticorps sna2, anticorps snail2, anticorps cb643, anticorps sna-1, anticorps sna1, anticorps snai1, anticorps snail1a, anticorps zgc:109820, anticorps snail family transcriptional repressor 1, anticorps snail family zinc finger 1, anticorps snail homolog 1 (Drosophila), anticorps snail, anticorps zinc-finger transcription factor Snail, anticorps snail family zinc finger 1 S homeolog, anticorps protein escargot, anticorps transcription factor protein, anticorps snail zinc finger protein, anticorps snail family zinc finger 1b, anticorps snail family zinc finger 1a, anticorps SNAI1, anticorps Snai1, anticorps sna, anticorps snail, anticorps snai1.S, anticorps LOC410464, anticorps snai1b, anticorps snai1a
Sujet
Zinc finger protein SNAI1 (SNAIL) is a zinc finger transcriptional repressor which down regulates the expression of ectodermal gene within the mesoderm and thus functions to form the mesoderm and neural crest. It is reported that SNAI1 acts as an important factor of tumor invasion as evidenced by its role in E-cadherin down-regulation and induction of epithelial-mesenchymal transition (EMT). In human breast cancer, the expression of SNAI1 and/or the homologous SNAI2 (Slug) has been associated with E-cadherin repression, local or distant metastasis, tumor recurrence, or poor prognosis in different tumor series. It is also reported that Snail 1 protein in the stroma may be a new putative prognosis marker for colon tumors. In recent studies SNAI1 is found to be potential target for proteasome degradation by hypoxia-controlled FBXL14 ubiquitin ligase targets.Synonyms: Protein snail homolog 1, SNAH, Zinc finger protein SNAI1
ID gène
6615
NCBI Accession
NP_005976
UniProt
O95863
Pathways
Negative Regulation of intrinsic apoptotic Signaling
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